protein

DRD3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DRD3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Drd3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	DRD3PROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the limbic system, making it a key player in reward processing, emotional regulation, and motivational behavior
Subcellular Localization	** \| Plasma membrane, dendrites, synapses \|
Molecular Weight	130 kDa
GeneCards	DRD3PROTEIN
Human Protein Atlas	DRD3PROTEIN
N-terminal extracellular domain	Contains glycosylation sites for proper folding and trafficking
Transmembrane domains (TM1-TM7)	Seven alpha-helices that span the plasma membrane
Three extracellular loops (ECL1-ECL3)	Involved in ligand binding, particularly dopamine and therapeutic compounds
Three intracellular loops (ICL1-ICL3)	Couple to G proteins for signal transduction
C-terminal intracellular tail	Contains serine/threonine residues for phosphorylation and desensitization
Inhibition of adenylate cyclase	Couples to Gi/o proteins, reducing cAMP production
Modulation of ion channels	Activates inward-rectifier potassium channels (GIRKs), hyperpolarizing neurons
Associated Diseases	neurodegeneration
Known Drugs/Compounds	D-520
Interactions	AMPK, DRD2, ULK1
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

drd3 Protein

protein · 711 words

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Pathway Diagram

graph TD
    DRD3PROTEIN["DRD3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    DRD3PROTEIN -->|"implicated_in"| neurodegeneration
    style DRD3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DRD3PROTEIN in their description or question text

No additional research found