protein

DYNAMIN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNAMIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4Connections

0Hypotheses

0Analyses

4Outgoing

0Incoming

0Experiments

0Debates

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🔬 Protein Info

Gene Symbol	DYNAMIN1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons, where it mediates the final scission of synaptic vesicles from the plasma membrane
Molecular Weight	100 kDa
GeneCards	DYNAMIN1
Human Protein Atlas	DYNAMIN1
Human Brain Expression	Searchable expression data across brain regions
Cell Type Specificity	Expression patterns in different neuronal populations
GTPase domain	N-terminal domain that hydrolyzes GTP to drive membrane fission
Middle domain	Mediates dimerization and oligomerization
Pleckstrin homology (PH) domain	Binds phosphatidylinositol 4,5-bisphosphate (PIP2) at the neck of clathrin-coated vesicles
GTPase effector domain (GED)	Stimulates GTPase activity; functions in self-assembly
Synaptic vesicle recycling	Critical for regenerating synaptic vesicles after neurotransmitter release
Clathrin-mediated endocytosis	Functions as the mechanical engine for vesicle scission
Activity-dependent endocytosis	Dynamin-1 is phosphorylated in a calcium/calmodulin-dependent manner
Associated Diseases	neurodegeneration
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Dynamin-1 Protein (DNM1)

protein · 713 words

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Pathway Diagram

flowchart TD
    N0["DYNAMIN1"]
    N1["TREM2"]
    N0 -->|"associated with"| N1
    N2["microglia"]
    N0 -->|"expressed in"| N2
    N3["neurodegeneration"]
    N0 -->|"contributes to"| N3
    N4["neurons"]
    N0 -->|"associated with"| N4
    N5["oligodendrocytes"]
    N0 -->|"associated with"| N5
    N0 -->|"implicated in"| N3

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene

Outgoing (4)

Target	Relation	Type	Str
TREM2	associated_with	gene	0.80
microglia	expressed_in	cell_type	0.80
neurons	associated_with	cell_type	0.70
oligodendrocytes	associated_with	cell_type	0.70

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DYNAMIN1 in their description or question text

No additional research found