gene

DYNC1LI2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DYNC1LI2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DYNC1LI2 (Dynein Cytoplasmic 1 Light Intermediate Chain 2) is a component of the cytoplasmic dynein complex, essential for retrograde axonal transport, organelle positioning, and neuronal survival.

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🧬 Gene Info

Gene Symbol	DYNC1LI2
Full Name	Dynein Cytoplasmic 1 Light Intermediate Chain 2
Chromosome	15q21.3
Function	encodes a critical component of the cytoplasmic dynein-1 complex, the primary motor responsible for retrograde axonal transport in neurons.
Molecular Weight	50 kDa
Amino Acids	523 aa
Ensembl ID	ENSG00000170840
GeneCards	DYNC1LI2
Human Protein Atlas	DYNC1LI2
Nucleus	Positioning in cell body
Golgi apparatus	Perinuclear localization
Lysosomes	Clustering near centrosome
Endosomes	Vesicular distribution
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DYNC1LI2 Gene

gene · 1464 words

→

DYNC1LI2 Protein

protein · 775 words

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Pathway Diagram

graph TD
    DYNC1LI2["DYNC1LI2"]
    neurodegeneration["neurodegeneration"]
    DYNC1LI2 -->|"implicated_in"| neurodegeneration
    style DYNC1LI2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning DYNC1LI2 in their description or question text

No additional research found