Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EGR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | EGR3 |
| Full Name | Early Growth Response 3 |
| Chromosome | 8p21.3 |
| Protein Type | Transcription Factor |
| Function | is an immediate-early gene encoding a zinc-finger transcription factor critical for neuronal development, synaptic plasticity, and cognitive function. |
| Molecular Weight | 46 kDa |
| Amino Acids | 426 aa |
| UniProt ID | Q9UKR3 |
| NCBI Gene ID | 1960 |
| Ensembl ID | ENSG00000179388 |
| OMIM | 602544 |
| GeneCards | EGR3 |
| Human Protein Atlas | EGR3 |
| Target Gene | Function |
| BDNF | Neurotrophin, synaptic plasticity |
| Associated Diseases | ALS |
| Interactions | AKT3, CASP1, CLEC7A |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["EGR3"]
N1["ALS"]
N0 -->|"associated with"| N1
N2["neurodegeneration"]
N0 -->|"implicated in"| N2
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease| Target | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | disease | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||