gene

CASP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

851Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CASP1 - Caspase 1, key inflammatory caspase regulating pyroptosis, inflammasome activation, and neuroinflammation in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	CASP1
Aliases	Caspase-1, ICE, IL-1β converting enzyme
Chromosome	11q22.3
Protein Type	Protease
Target Class	Protease
Function	Small molecule covalent inhibitor of caspase-1 proteolytic activity
Mechanism of Action	Small molecule covalent inhibitor of caspase-1 proteolytic activity
Druggability	Medium (0.46)
Clinical Stage	Phase II
Molecular Weight	45 kDa
Amino Acids	404 aa
Exons	11
Pathways	NF-κB
UniProt ID	P29465
NCBI Gene ID	842
GeneCards	CASP1
Human Protein Atlas	CASP1
Associated Diseases	ALS, ALZHEIMER, Aging, Atherosclerosis, Cancer
Known Drugs/Compounds	Pterostilbene, KAEMPFEROL, rapamycin
Interactions	NLRP3, IL1B, PYCARD, SNCA, ASC, SQSTM1
SciDEX Target	View Target Profile (3 clinical trials)
KG Connections	851 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: CASP1 — PDB 1ICE Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CASP1["CASP1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CASP1["CASP1"] -->|"interacts"| NLRP3["NLRP3"]
    CASP1["CASP1"] -->|"interacts"| IL1B["IL1B"]
    CASP1["CASP1"] -->|"interacts"| PYCARD["PYCARD"]
    CASP1["CASP1"] -.->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    CASP1["CASP1"] -.->|"inhibits"| Inflammation["Inflammation"]
    h_e7e1f943["h-e7e1f943"] -->|"therapeutic target"| CASP1["CASP1"]
    NLRP3_1["NLRP3"] -->|"interacts"| CASP1["CASP1"]
    IL1B_2["IL1B"] -->|"interacts"| CASP1["CASP1"]
    PYCARD_3["PYCARD"] -->|"interacts"| CASP1["CASP1"]
    style CASP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (588)

Target	Relation	Type	Str
GSDMD	activates	gene	0.95
NLRP3	co_mentioned_with	gene	0.90
GSDMD	associated_with	protein	0.90
GSDMD	phosphorylates	protein	0.90
IL-1β	activates	protein	0.90
Pyroptosis	involved_in	process	0.90
PARKINSON'S DISEASE	biomarker_for	disease	0.88
PANoptosis	mediates	process	0.85
IL18	upregulates	gene	0.85
Tumor	associated_with	disease	0.85
IL1B	co_mentioned_with	gene	0.80
cerebral ischemia-reperfusion injury	contributes_to	disease	0.80
atherosclerosis	causes	disease	0.80
oxidative stress response	participates_in	pathway	0.80
autophagy pathway	participates_in	pathway	0.80
ubiquitin-proteasome	participates_in	pathway	0.80
TNF	associated_with	gene	0.80
Neurodegeneration	inhibits	disease	0.75
Inflammation	activates	disease	0.75
ATG7	associated_with	gene	0.70
IL1B	associated_with	gene	0.70
IL18	associated_with	gene	0.70
IL1B	regulates	gene	0.70
CNP	activates	gene	0.70
Autophagy	associated_with	pathway	0.70
Inflammasome	activates	pathway	0.70
APOPTOSIS	associated_with	gene	0.70
Apoptosis	associated_with	pathway	0.70
Toll-Like Receptor	associated_with	pathway	0.70
pyroptosis	participates_in	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
neurodegeneration	associated_with	disease	0.65
NLRP3	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
PYCARD	interacts_with	gene	0.65
TAU	associated_with	gene	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Ms	activates	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Inflammation	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Ms	protects_against	disease	0.65
Alzheimer	activates	disease	0.65

Incoming (263)

Source	Relation	Type	Str
QINGQI LIANGYING FORMULA	inhibits	gene	0.95
GS-1	downregulates	compound	0.90
Pterostilbene	inhibits	compound	0.90
KAEMPFEROL	inhibits	drug	0.90
h-e7e1f943	targets_gene	hypothesis	0.90
h-var-6957745fea	targets_gene	hypothesis	0.90
h-var-08a4d5c07a	targets_gene	hypothesis	0.90
h-var-d04a952932	targets_gene	hypothesis	0.90
h-var-adfecef68a	targets_gene	hypothesis	0.90
h-var-af9eb8e59b	targets_gene	hypothesis	0.90
h-var-a0933e666d	targets_gene	hypothesis	0.90
Kaempferol	downregulates	compound	0.88
NLRP3 inflammasome	activates	pathway	0.88
GEGEN QINLIAN DECOCTION	downregulates	drug	0.85
Irisin	downregulates	protein	0.85
USP22	inhibits	protein	0.85
Nlrp3 Inflammasome	activates	process	0.85
h-e7e1f943	targets	hypothesis	0.80
TNFR1	activates	gene	0.80
ATG5	associated_with	gene	0.70
NLRP3	associated_with	gene	0.70
AIM2	associated_with	gene	0.70
ASC	associated_with	gene	0.70
PYCARD	associated_with	gene	0.70
LAMP1	associated_with	gene	0.70
LC3	associated_with	gene	0.70
NEURODEGENERATION	inhibits	gene	0.70
AUTOPHAGY	associated_with	gene	0.70
MACROPHAGES	inhibits	cell_type	0.70
NLRP3	interacts_with	gene	0.65
IL1B	interacts_with	gene	0.65
PYCARD	interacts_with	gene	0.65
ASTROCYTES	activates	cell_type	0.65
NLRP3 INFLAMMASOME	degrades	pathway	0.65
NLRP3 INFLAMMASOME	causes	pathway	0.65
PYROPTOSIS	regulates	phenotype	0.65
PYROPTOSIS	degrades	phenotype	0.65
ACTB	associated_with	gene	0.60
IL1B	inhibits	gene	0.60
IL6	inhibits	gene	0.60
IL1B	associated_with	gene	0.60
IL18	associated_with	gene	0.60
SQSTM1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
MAP1LC3B	inhibits	gene	0.60
TNF	associated_with	gene	0.60
MARCH7	associated_with	gene	0.60
NLRC4	associated_with	gene	0.60
ATG5	co_discussed	gene	0.60
AIF1	co_discussed	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CASP1

Understanding Entity Pages

Summary

Wiki Pages (21)

CASP1 Gene

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CBS/PSP Supplements Guide

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Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Sulforaphane and Nrf2 Activation for Neuroprotection

Coenzyme Q10 for Neurodegeneration

deferiprone-neurodegeneration

vitamin-d-therapy-neurodegeneration

Neuroprotection Strategies in Neurodegeneration

Curcumin for Neurodegeneration

Mediterranean and MIND Diets for Neurodegeneration

creatine-supplementation-neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

Ambroxol for Neurodegeneration (GCase Chaperone Strategy)

NAD+ Precursors for Neurodegeneration

Creatine for Neuroprotection

tudca-udca-neurodegeneration

alpha-lipoic-acid-neurodegeneration