gene

CLEC7A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLEC7A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

49Connections
0Hypotheses
0Analyses
36Outgoing
13Incoming

Summary

CLEC7A is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Parkinson's disease, ischemic stroke. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCLEC7A
Protein TypeReceptor
FunctionCLEC7A encodes a type II transmembrane protein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like hemITAM.
PathwaysAmyloid, unfolded protein response, lipid metabolism
Ensembl IDENSG00000172243
GeneCardsCLEC7A
Human Protein AtlasCLEC7A
NFATgene transcription for immune activation
CARD9/BCL10/MALT1inflammasome-independent cytokine production
Associated DiseasesParkinson's disease, ischemic stroke
InteractionsSyk, TREM2, CTSB, CTSD, CTSL, GPNMB
KG Connections49 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (19)

Knowledge base pages for this entity

Canonical Page

CLEC7A Gene

gene · 939 words

Microglia Activation Mechanism

mechanism · 3164 words

SYK Kinase in Microglial Activation and Alzheimer's Disease

mechanism · 2557 words

Microglial State Trajectory from Mobilization to Dysregulation in Alzheimer's Disease

mechanism · 2523 words

iPSC-Derived Microglia

cell · 2432 words

Microglial Dysfunction in Alzheimer's Disease

mechanism · 2063 words

Pathway Diagram

graph TD
    CLEC7A["<b>CLEC7A</b>"]
    Parkinson_s_disease{"Parkinson's disease"}
    CLEC7A -->|"associated with"| Parkinson_s_disease
    neuroinflammation["neuroinflammation"]
    CLEC7A -->|"regulates"| neuroinflammation
    ischemic_stroke{"ischemic stroke"}
    CLEC7A -->|"associated with"| ischemic_stroke
    synapse_elimination["synapse elimination"]
    CLEC7A -->|"regulates"| synapse_elimination
    Gal3["Gal3"]
    CLEC7A -->|"regulates"| Gal3
    TREM2["TREM2"]
    CLEC7A -->|"regulates"| TREM2
    Syk["Syk"]
    CLEC7A -->|"activates"| Syk
    NOX2["NOX2"]
    CLEC7A -->|"regulates"| NOX2
    phagocytosis["phagocytosis"]
    CLEC7A -->|"regulates"| phagocytosis
    pyroptosis["pyroptosis"]
    CLEC7A -->|"regulates"| pyroptosis
    microglia_activation["microglia activation"]
    CLEC7A -->|"regulates"| microglia_activation
    neurodegeneration["neurodegeneration"]
    CLEC7A -->|"implicated in"| neurodegeneration
    style CLEC7A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (36)

TargetRelationTypeStr
ischemic strokeassociated_withdisease0.90
synapse eliminationregulatesbiological_process0.90
Parkinson's diseaseassociated_withdisease0.90
Gal3regulatesprotein0.80
TREM2regulatesgene0.80

Incoming (13)

SourceRelationTypeStr
APOEactivatesgene0.60
AKT3activatesgene0.60
CASP1activatesgene0.60
NEURODEGENERATIONactivatesgene0.60
ALZHEIMERactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found