Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLEC7A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CLEC7A is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, implicated in. Associated with Parkinson's disease, ischemic stroke. Connected to 12 entities in the SciDEX knowledge graph.
| Gene Symbol | CLEC7A |
| Protein Type | Receptor |
| Function | CLEC7A encodes a type II transmembrane protein with an extracellular C-type lectin domain and an intracellular immunoreceptor tyrosine-based activation motif (ITAM)-like hemITAM. |
| Pathways | Amyloid, unfolded protein response, lipid metabolism |
| Ensembl ID | ENSG00000172243 |
| GeneCards | CLEC7A |
| Human Protein Atlas | CLEC7A |
| NFAT | gene transcription for immune activation |
| CARD9/BCL10/MALT1 | inflammasome-independent cytokine production |
| Associated Diseases | Parkinson's disease, ischemic stroke |
| Interactions | Syk, TREM2, CTSB, CTSD, CTSL, GPNMB |
| KG Connections | 49 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CLEC7A["<b>CLEC7A</b>"]
Parkinson_s_disease{"Parkinson's disease"}
CLEC7A -->|"associated with"| Parkinson_s_disease
neuroinflammation["neuroinflammation"]
CLEC7A -->|"regulates"| neuroinflammation
ischemic_stroke{"ischemic stroke"}
CLEC7A -->|"associated with"| ischemic_stroke
synapse_elimination["synapse elimination"]
CLEC7A -->|"regulates"| synapse_elimination
Gal3["Gal3"]
CLEC7A -->|"regulates"| Gal3
TREM2["TREM2"]
CLEC7A -->|"regulates"| TREM2
Syk["Syk"]
CLEC7A -->|"activates"| Syk
NOX2["NOX2"]
CLEC7A -->|"regulates"| NOX2
phagocytosis["phagocytosis"]
CLEC7A -->|"regulates"| phagocytosis
pyroptosis["pyroptosis"]
CLEC7A -->|"regulates"| pyroptosis
microglia_activation["microglia activation"]
CLEC7A -->|"regulates"| microglia_activation
neurodegeneration["neurodegeneration"]
CLEC7A -->|"implicated in"| neurodegeneration
style CLEC7A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ischemic stroke | associated_with | disease | 0.90 |
| synapse elimination | regulates | biological_process | 0.90 |
| Parkinson's disease | associated_with | disease | 0.90 |
| Gal3 | regulates | protein | 0.80 |
| TREM2 | regulates | gene | 0.80 |
| Syk | activates | protein | 0.80 |
| NOX2 | regulates | protein | 0.80 |
| microglia activation | regulates | biological_process | 0.80 |
| Alzheimer | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| TREM2 | activates | gene | 0.60 |
| EGR3 | activates | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| MIR-155 | activates | gene | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| AND | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | activates | gene | 0.60 |
| Amyloid | activates | pathway | 0.60 |
| CTSB | activates | gene | 0.55 |
| CTSD | activates | gene | 0.55 |
| CTSL | activates | gene | 0.55 |
| GPNMB | activates | gene | 0.55 |
| LGALS3 | activates | gene | 0.55 |
| LPL | activates | gene | 0.55 |
| SPP1 | activates | gene | 0.55 |
| TYROBP | activates | gene | 0.55 |
| LIPA | activates | gene | 0.55 |
| Microglia | expressed_in | cell_type | 0.55 |
| unfolded protein response | participates_in | pathway | 0.55 |
| DAM microglia | expressed_in | cell_type | 0.55 |
| lipid metabolism | participates_in | pathway | 0.55 |
| ALZHEIMER'S | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | activates | gene | 0.60 |
| AKT3 | activates | gene | 0.60 |
| CASP1 | activates | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| MIR-155 | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| AXL | activates | gene | 0.55 |
| CD9 | activates | gene | 0.55 |
| microglia | activates | cell_type | 0.50 |
| GALECTIN-3 | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||