protein

AKT3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AKT3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

171Connections

0Hypotheses

0Analyses

50Outgoing

49Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	AKT3
Full Name	AKT Serine/Threonine Kinase 3
Aliases	PKB-gamma, RAC-gamma
Chromosome	1q43-q44
Protein Type	Kinase
Function	Serine/threonine kinase regulating brain development and neuronal survival
Primary Expression	substantia nigra dopaminergic neurons
Molecular Weight	55.8 kDa
Amino Acids	479
Pathways	PI3K-AKT signaling, mTOR pathway
UniProt ID	O95886
NCBI Gene ID	10000
Ensembl ID	ENSG00000163660
OMIM	611495
GeneCards	AKT3
Human Protein Atlas	AKT3
Associated Diseases	ALS, Aging, Atherosclerosis, Cancer, Cardiovascular
Interactions	NPRL2, PIK3CA, DEPDC5, NPRL3, RHEB, TSC2
KG Connections	171 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: AKT3 — AlphaFold Q9Y243 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AKT3["AKT3"] -->|"activates"| MTOR["MTOR"]
    style MTOR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    AKT3["AKT3"] -->|"regulates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AKT3["AKT3"] -->|"regulates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AKT3["AKT3"] -->|"associated"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AKT3["AKT3"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    style Carcinoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AKT3["AKT3"] -->|"therapeutic target"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AKT3["AKT3"] -->|"therapeutic target"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    AKT["AKT"] -->|"associated"| AKT3["AKT3"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    PIK3CA["PIK3CA"] -->|"therapeutic target"| AKT3["AKT3"]
    style PIK3CA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MTOR_1["MTOR"] -->|"therapeutic target"| AKT3["AKT3"]
    style MTOR_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    PIK3CD["PIK3CD"] -->|"therapeutic target"| AKT3["AKT3"]
    style PIK3CD fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MIRNAS["MIRNAS"] -->|"therapeutic target"| AKT3["AKT3"]
    style MIRNAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style AKT3 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (122)

Target	Relation	Type	Str
MTOR	activates	protein	0.70
mTOR	activates	protein	0.70
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Aging	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	implicated_in	disease	0.65
Atherosclerosis	implicated_in	disease	0.65
Cardiovascular	implicated_in	disease	0.65
Als	associated_with	disease	0.65
Als	implicated_in	disease	0.65
Epilepsy	associated_with	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Epilepsy	activates	disease	0.65
AKT	associated_with	gene	0.60
PI3K	regulates	gene	0.60
MTOR	regulates	gene	0.60
AKT2	associated_with	gene	0.60
AKT1	associated_with	gene	0.60
PIK3CB	therapeutic_target	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
EGFR	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
RHEB	associated_with	gene	0.60
NPRL2	activates	gene	0.60
PIK3CA	activates	gene	0.60
DEPDC5	activates	gene	0.60
NPRL3	activates	gene	0.60
RHEB	activates	gene	0.60
TSC2	activates	gene	0.60
TSC1	activates	gene	0.60
TNF	therapeutic_target	gene	0.60
GNAI3	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
PTEN	therapeutic_target	gene	0.60
MTOR	associated_with	gene	0.60
FGFR1	associated_with	gene	0.60
NRAS	associated_with	gene	0.60

Incoming (49)

Source	Relation	Type	Str
AKT	associated_with	gene	0.70
PIK3CA	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
PIK3CD	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
PIK3R3	therapeutic_target	gene	0.60
AKT1	associated_with	gene	0.60
AKT2	associated_with	gene	0.60
OVERVIEW	implicated_in	gene	0.60
PI3K	associated_with	gene	0.60
PIK3R2	associated_with	gene	0.60
PIK3CA	associated_with	gene	0.60
AKT1	implicated_in	gene	0.60
AKT2	implicated_in	gene	0.60
PI3K	inhibits	gene	0.60
AKT	implicated_in	gene	0.60
PIK3CB	therapeutic_target	gene	0.60
NRAS	associated_with	gene	0.60
NF1	associated_with	gene	0.60
DYRK1A	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
FGFR1	associated_with	gene	0.60
MTOR	activates	gene	0.60
MYC	therapeutic_target	gene	0.60
TSC1	activates	gene	0.60
RHEB	associated_with	gene	0.60
BRAF	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
PTEN	associated_with	gene	0.60
RHEB	activates	gene	0.60
TSC2	activates	gene	0.60
NPRL3	activates	gene	0.60
PIK3CA	activates	gene	0.60
NPRL2	activates	gene	0.60
DEPDC5	activates	gene	0.60
MIRNAS	therapeutic_target	gene	0.60
CANCER	implicated_in	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
EPILEPSY	associated_with	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60
EXOSOMES	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
EPILEPSY	activates	gene	0.60
KRAS	associated_with	gene	0.60
EGFR	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AKT3

Understanding Entity Pages

Wiki Pages (18)

AKT3 Gene

AKT2 Gene

PDPK1 Gene

pi3k-akt-signaling

Akt Signaling Pathway in Neurodegeneration

PI3K/Akt Signaling in Neurodegeneration

PI3K-Akt Signaling in Parkinson's Disease

AKT1 Protein

AKT (Protein Kinase B) Neurons

AKT1 Protein (Protein Kinase B Alpha)

PIK3R2 Gene

AKT1 Gene

akt-protein

EGR3 — Early Growth Response 3

AKT3 Protein

AKT2 Protein