Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Endosomal sorting / vesicle trafficking: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CHMP4B | participates_in | gene | 0.34 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Extracellular Vesicle Biogenesis Modulation | 0.340 | Alzheimer's Disease | Tau propagation mechanisms and therapeut |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Pyroptosis drives tumor progression and immune evasion in Hepatocellular Carcino [PMID:40394449] | Tao S, Yang Y | Discover oncology | 2025 | 0 |
| Classical swine fever virus recruits ALIX and ESCRT-III to facilitate viral budd [PMID:39998268] | ["Chen J", "Yang H", "Wan M", "Cheng Y", | mBio | 2025 | 0 |
| Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene [PMID:37409482] | ["Li X", "La Salvia S", "Liang Y", "Adam | Circulation | 2023 | 0 |
| Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes a [PMID:36642728] | ["Zou J", "Yang W", "Cui W", "Li C", "Ma | Journal of nanobiotechnology | 2023 | 0 |
| Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge dur [PMID:37523003] | Pust S, Brech A, Wegner CS, Stenmark H, | Cellular and molecular life sc | 2023 | 0 |
| The endosomal sorting complex required for transport repairs the membrane to del [PMID:36330465] | ["Yang Y", "Wang M", "Zhang Y", "Zhao S" | Frontiers in oncology | 2022 | 0 |
| ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes. [PMID:32049272] | ["Larios J", "Mercier V", "Roux A", "Gru | The Journal of cell biology | 2020 | 0 |
| ESCRT-mediated phagophore sealing during mitophagy. [PMID:31366282] | Zhen Y, Spangenberg H, Munson MJ, Brech | Autophagy | 2020 | 0 |
| Distribution of colorectal polyps: Implications for screening. [PMID:28842058] | ["Senore C", "Bellisario C", "Segnan N"] | Best practice & research. Clin | 2017 | 0 |
| Mutational signatures indicative of environmental stress in bacteria. [PMID:25389207] | ["Maharjan R", "Ferenci T"] | Molecular biology and evolutio | 2015 | 0 |
| [Treating asthma in children successfully: 10 tips]. [PMID:23657095] | Brand P, de Jongste J | Nederlands tijdschrift voor ge | 2013 | 0 |
| Serine starvation induces stress and p53-dependent metabolic remodelling in canc [PMID:23242140] | ["Maddocks O", "Berkers C", "Mason S", " | Nature | 2013 | 0 |
| ASIC3, a sensor of acidic and primary inflammatory pain. [PMID:18923424] | ["Deval E", "No\u00ebl J", "Lay N", "All | The EMBO journal | 2008 | 0 |
| Multiple substrate binding by cytochrome P450 3A4: estimation of the number of b [PMID:18645035] | ["Kapelyukh Y", "Paine M", "Mar\u00e9cha | Drug metabolism and dispositio | 2008 | 0 |
| Roles of ESCRT in autophagy-associated neurodegeneration. [PMID:18094607] | Lee JA, Gao FB | Autophagy | 2008 | 0 |