gene

CHMP4B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

334Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Page for CHMP4B — Charged Multivesicular Body Protein 4B

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🧬 Gene Info

Gene Symbol	CHMP4B
Full Name	Charged Multivesicular Body Protein 4B
Chromosome	20q11.22
Protein Type	Other
Target Class	Other
Function	The ESCRT machinery mediates the final steps of multivesicular body formation through sequential recruitment and polymerization of ESCRT-III components.
Mechanism of Action	CHMP4B-targeting drugs would inhibit or modulate ESCRT-III complex assembly and membrane scission, disrupting cellular degradation pathways (autophagy, lysosomal trafficking) and potentially inhibiting viral budding or cancer cell survival. Therapeutics could involve blocking protein-protein interactions within the ESCRT complex or stabilizing/destabilizing CHMP4B conformational states.
Primary Expression	most human tissues, with particularly high expression in: - Eye: Lens epithelial cells and fiber cells — explaining its role in cataract - Centr
Druggability	Low (0.30)
Clinical Stage	Phase II
Molecular Weight	25 kDa
Amino Acids	224 aa
Pathways	ESCRT-III, Extracellular Vesicle Biogenesis Modulation, autophagy, ferroptosis, mitophagy
UniProt ID	Q9H444
Ensembl ID	ENSG00000101421
GeneCards	CHMP4B
Human Protein Atlas	CHMP4B
Associated Diseases	ALS, ALZHEIMER, Alzheimer's Disease, HUNTINGTON, INFLAMMATION
Known Drugs/Compounds	ML-SI3 (ESCRT modulator), Spautin-1, VPS34 inhibitors (SAR405, VPS34-IN1), ALIX antagonists (investigational)
Interactions	RAB7A, MAPT, GBM, GPX4, KIF4A, CHMP2B
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Extracellular Vesicle Biogenesis Modulation
KG Connections	334 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CHMP4B — AlphaFold Q9H444 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHMP4B["<b>CHMP4B</b>"]
    Extracellular_Vesicle_Biogenesis_Modulat["Extracellular Vesicle Biogenesis Modulation"]
    CHMP4B -->|"regulates"| Extracellular_Vesicle_Biogenesis_Modulat
    Als{"Als"}
    CHMP4B -->|"activates"| Als
    Cancer{"Cancer"}
    CHMP4B -->|"activates"| Cancer
    Tau_Propagation["Tau Propagation"]
    CHMP4B -->|"regulates"| Tau_Propagation
    CANCER["CANCER"]
    CHMP4B -->|"activates"| CANCER
    RAB7A["RAB7A"]
    CHMP4B -->|"activates"| RAB7A
    APOPTOSIS["APOPTOSIS"]
    CHMP4B -->|"activates"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    CHMP4B -->|"activates"| Apoptosis
    neurodegeneration["neurodegeneration"]
    CHMP4B -->|"implicated in"| neurodegeneration
    h_55ef81c5["h-55ef81c5"]
    h_55ef81c5 -->|"therapeutic target"| CHMP4B
    h_55ef81c5 -->|"targets"| CHMP4B
    style CHMP4B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (265)

Target	Relation	Type	Str
MAPT	regulates	protein	0.85
endosome	transported_by	organelle	0.80
Extracellular Vesicle Biogenesis Modulation	regulates	mechanism	0.70
microglia	inhibits	cell_type	0.70
microglia	regulates	cell_type	0.70
hippocampus	expressed_in	brain_region	0.70
neurons	associated_with	cell_type	0.70
microglia	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Ferroptosis	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Pyroptosis	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Autism	interacts_with	disease	0.65
Alzheimer	activates	disease	0.65
Als	inhibits	disease	0.65
Necroptosis	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	interacts_with	disease	0.65
ALS	inhibits	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Inflammation	activates	disease	0.65
Tau Propagation	regulates	biological_process	0.60
RAB7A	activates	gene	0.60
neuronal pruning	involved_in	pathway	0.60
cataract	causes	disease	0.60
ferroptosis	regulates	pathway	0.60
GSDMD	inhibits	protein	0.60
autophagy	involved_in	pathway	0.60
rabies virus	associated_with	disease	0.60
CD68	expressed_in	gene	0.60
CHMP2B	activates	gene	0.60
CHMP7	interacts_with	gene	0.60
VPS4	interacts_with	gene	0.60
DNAJB6	associated_with	gene	0.60
VPS37B	associated_with	gene	0.60
TAU	activates	gene	0.60
MAPT	inhibits	gene	0.60
TAU	inhibits	gene	0.60
FOXO1	activates	gene	0.60
FAS	expressed_in	gene	0.60
Rb	expressed_in	protein	0.60
GPX4	inhibits	gene	0.60
ferroptosis	participates_in	pathway	0.60
GPX4	promotes	gene	0.60

Incoming (69)

Source	Relation	Type	Str
h-55ef81c5	targets_gene	hypothesis	0.90
h-55ef81c5	targets	hypothesis	0.80
MAPT	decreases	gene	0.80
β2-AR	activates	protein	0.80
AR	activates	gene	0.70
KIF4A	interacts_with	protein	0.60
CHMP2A	interacts_with	protein	0.60
CC2D1A	interacts_with	protein	0.60
CD68	expressed_in	gene	0.60
GBM	activates	gene	0.60
KIF4A	activates	gene	0.60
GSDMD	inhibits	gene	0.60
CHMP2B	activates	gene	0.60
CHMP7	interacts_with	gene	0.60
DNAJB6	associated_with	gene	0.60
VPS37B	associated_with	gene	0.60
TAU	inhibits	gene	0.60
MAPT	inhibits	gene	0.60
FOXO1	activates	gene	0.60
FAS	expressed_in	gene	0.60
VPS4	interacts_with	gene	0.60
CHMP2B	associated_with	gene	0.60
CHMP2B	interacts_with	gene	0.60
CHMP2B	promotes	gene	0.60
autophagy	regulates	pathway	0.60
CHMP2A	regulates	gene	0.60
ENDOSOME	interacts_with	gene	0.60
DNA	associated_with	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
ROS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
PYROPTOSIS	inhibits	gene	0.60
ROS	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
ALS	activates	gene	0.60
EXERCISE	activates	gene	0.60
EXERCISE	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
APOPTOSIS	associated_with	gene	0.60
RNA	associated_with	gene	0.60
GENES	inhibits	gene	0.60
LYSOSOME	activates	gene	0.60
LYSOSOME	inhibits	gene	0.60
ALZHEIMER DISEASE	inhibits	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
FASL	activates	gene	0.60
ALS	associated_with	gene	0.60
apoptosis	binds_to	pathway	0.60
CD9	co_mentioned	gene	0.55

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Extracellular Vesicle Biogenesis Modulation	0.340	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (1)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Pyroptosis drives tumor progression and immune evasion in Hepatocellular Carcino [PMID:40394449]	Tao S, Yang Y	Discover oncology	2025
Classical swine fever virus recruits ALIX and ESCRT-III to facilitate viral budd [PMID:39998268]	["Chen J", "Yang H", "Wan M", "Cheng Y",	mBio	2025
Extracellular Vesicle-Encapsulated Adeno-Associated Viruses for Therapeutic Gene [PMID:37409482]	["Li X", "La Salvia S", "Liang Y", "Adam	Circulation	2023
Therapeutic potential and mechanisms of mesenchymal stem cell-derived exosomes a [PMID:36642728]	["Zou J", "Yang W", "Cui W", "Li C", "Ma	Journal of nanobiotechnology	2023
Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge dur [PMID:37523003]	Pust S, Brech A, Wegner CS, Stenmark H,	Cellular and molecular life sc	2023
The endosomal sorting complex required for transport repairs the membrane to del [PMID:36330465]	["Yang Y", "Wang M", "Zhang Y", "Zhao S"	Frontiers in oncology	2022
ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes. [PMID:32049272]	["Larios J", "Mercier V", "Roux A", "Gru	The Journal of cell biology	2020
ESCRT-mediated phagophore sealing during mitophagy. [PMID:31366282]	Zhen Y, Spangenberg H, Munson MJ, Brech	Autophagy	2020
Distribution of colorectal polyps: Implications for screening. [PMID:28842058]	["Senore C", "Bellisario C", "Segnan N"]	Best practice & research. Clin	2017
Mutational signatures indicative of environmental stress in bacteria. [PMID:25389207]	["Maharjan R", "Ferenci T"]	Molecular biology and evolutio	2015
[Treating asthma in children successfully: 10 tips]. [PMID:23657095]	Brand P, de Jongste J	Nederlands tijdschrift voor ge	2013
Serine starvation induces stress and p53-dependent metabolic remodelling in canc [PMID:23242140]	["Maddocks O", "Berkers C", "Mason S", "	Nature	2013
ASIC3, a sensor of acidic and primary inflammatory pain. [PMID:18923424]	["Deval E", "No\u00ebl J", "Lay N", "All	The EMBO journal	2008
Multiple substrate binding by cytochrome P450 3A4: estimation of the number of b [PMID:18645035]	["Kapelyukh Y", "Paine M", "Mar\u00e9cha	Drug metabolism and dispositio	2008
Roles of ESCRT in autophagy-associated neurodegeneration. [PMID:18094607]	Lee JA, Gao FB	Autophagy	2008

CHMP4B

Understanding Entity Pages

Summary

Wiki Pages (21)

CHMP4B — Charged Multivesicular Body Protein 4B

Alpha-Synuclein ESCRT-III Inhibition Mechanism

Exosome Biogenesis in Neurodegeneration

CHMP1A — Charged Multivesicular Body Protein 1A

ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration

ESCRT-III Neuroprotection Therapy for Neurodegeneration

Tau Propagation Mechanisms

Endosomal-Lysosomal Pathway in Neurodegeneration

CHMP3 — Charged Multivesicular Body Protein 3

CHMP4A — Charged Multivesicular Body Protein 4A

NTS — Neurotensin

CHMP2B — Charged Multivesicular Body Protein 2B

SPG21 Gene

Exosome-Mediated Tau Propagation in Progressive Supranuclear Palsy

VPS4A — Vacuolar Protein Sorting 4 Homolog A

ESCRT-III Inhibition by Alpha-Synuclein

CHMP2A

CHMP2B Protein

SPG20 Protein

Syntenin-1 Exosome Biogenesis Modulation Therapy for Neurodegeneration