gene

FASLG

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FASLG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1Connections

0Hypotheses

0Analyses

1Outgoing

0Incoming

0Experiments

0Debates

Summary

FASLG gene in neurodegeneration

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🧬 Gene Info

Gene Symbol	FASLG
Full Name	Fas Ligand
Chromosome	1q24.3
Protein Type	Gene
Function	is a gene encoding the Fas ligand (FasL/CD95L), a Type II transmembrane protein belonging to the tumor necrosis factor (TNF) superfamily.
Primary Expression	various tissues with notable patterns relevant to neurodegeneration: [@yang2006]
Molecular Weight	26 kDa
Pathways	NF-κB
UniProt ID	P48023
NCBI Gene ID	3564
GeneCards	FASLG
Human Protein Atlas	FASLG
Associated Diseases	neurodegeneration
KG Connections	1 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FASLG — AlphaFold P48023 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FASLG - Fas Ligand

gene · 990 words

→

FASLG Protein - Fas Ligand

protein · 750 words

→

Pathway Diagram

graph TD
    FASLG["FASLG Gene"]
    FASLG_protein["FasL Protein"]
    FAS_receptor["Fas Receptor"]
    FADD["FADD Adapter"]
    Caspase8["Caspase-8"]
    Caspase3["Caspase-3"]
    Apoptosis["Apoptosis"]
    Neuronal_death["Neuronal Death"]
    Neurodegeneration["Neurodegeneration"]
    TNF_alpha["TNF-alpha"]
    Microglia["Activated Microglia"]
    Inflammation["Neuroinflammation"]
    NFkB["NF-kappaB Pathway"]
    P53["p53 Tumor Suppressor"]
    BCL2["Bcl-2 Family"]
    Mitochondria["Mitochondrial Dysfunction"]

    FASLG -->|"transcribes"| FASLG_protein
    FASLG_protein -->|"binds"| FAS_receptor
    FAS_receptor -->|"recruits"| FADD
    FADD -->|"activates"| Caspase8
    Caspase8 -->|"cleaves"| Caspase3
    Caspase3 -->|"executes"| Apoptosis
    Apoptosis -->|"causes"| Neuronal_death
    Neuronal_death -->|"contributes to"| Neurodegeneration
    Microglia -->|"expresses"| FASLG_protein
    TNF_alpha -->|"upregulates"| FASLG
    Inflammation -->|"induces"| FASLG
    NFkB -->|"transcriptionally activates"| FASLG
    P53 -->|"upregulates"| FASLG
    BCL2 -->|"inhibits"| Apoptosis
    Caspase8 -->|"promotes"| Mitochondria

    style FASLG fill:#1a3a4a,stroke:#4fc3f7
    style FASLG_protein fill:#1a3a4a,stroke:#4fc3f7
    style BCL2 fill:#1a3a2a,stroke:#81c784
    style Apoptosis fill:#3a1a1a,stroke:#ef5350
    style Neuronal_death fill:#3a1a1a,stroke:#ef5350
    style Neurodegeneration fill:#3a2a1a,stroke:#ffa726
    style Inflammation fill:#3a1a1a,stroke:#ef5350
    style P53 fill:#2a1a3a,stroke:#ce93d8
    style NFkB fill:#2a1a3a,stroke:#ce93d8

Outgoing (1)

Target	Relation	Type	Str
Apoptosis	mediates	process	0.90

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FASLG in their description or question text

No additional research found