Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FZD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | FZD3 |
| Full Name | Frizzled Class Receptor 3 |
| Chromosome | 8p21.1 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the nervous system |
| Pathways | Wnt signaling, Wnt Signaling, Wnt |
| UniProt ID | Q9UPW4 |
| NCBI Gene ID | 7976 |
| Ensembl ID | ENSG00000104290 |
| OMIM | 605194 |
| GeneCards | FZD3 |
| Human Protein Atlas | FZD3 |
| Associated Diseases | Alzheimer's Disease, Schizophrenia, Autism Spectrum Disorder |
| Interactions | CTNNB1 |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
FZD3["<b>FZD3</b>"]
WNT(["WNT"])
FZD3 -->|"participates in"| WNT
FZD3 -->|"binds"| WNT
CTNNB1["CTNNB1"]
FZD3 -->|"activates"| CTNNB1
DVL["DVL"]
FZD3 -->|"binds"| DVL
STEM_CELLS["STEM_CELLS"]
FZD3 -->|"regulates"| STEM_CELLS
neurodegeneration["neurodegeneration"]
FZD3 -->|"implicated in"| neurodegeneration
style FZD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| CTNNB1 | activates | gene | 0.80 |
| WNT | participates_in | pathway | 0.80 |
| STEM_CELLS | regulates | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||