CTNNB1

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTNNB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CTNNB1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, activates. Associated with ALS, Aging, Als. Connected to 334 entities in the SciDEX knowledge graph.

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flowchart TD
    CTNNB1_gene["CTNNB1<br/>Gene"]
    beta_catenin["beta-Catenin<br/>Protein"]
    LRP1["LRP1<br/>Receptor"]
    TCF3["TCF3<br/>Transcription Factor"]
    AXIN2["AXIN2<br/>Wnt Regulator"]
    RRM1["RRM1<br/>DNA Repair"]
    SQSTM1["SQSTM1/p62<br/>Autophagy Adapter"]
    RAB7A["RAB7A<br/>Vesicle Transport"]
    
    ALS["Amyotrophic Lateral<br/>Sclerosis (ALS)"]
    MS["Multiple Sclerosis<br/>(MS)"]
    neuroinflammation["Neuroinflammation"]
    fibrosis["Tissue Fibrosis"]
    cancer["Cancer/Tumors"]
    
    wnt_signaling["Wnt Signaling<br/>Pathway"]
    cell_adhesion["Cell Adhesion<br/> and Migration"]
    synaptic_function["Synaptic Function<br/> and Plasticity"]
    
    CTNNB1_gene --|"encodes"|--> beta_catenin
    LRP1 --|"regulates"|--> beta_catenin
    beta_catenin --|"interacts_with"|--> TCF3
    beta_catenin --|"activates"|--> wnt_signaling
    beta_catenin --|"regulates"|--> cell_adhesion
    beta_catenin --|"modulates"|--> synaptic_function
    
    wnt_signaling --|"associated_with"|--> AXIN2
    beta_catenin --|"activates"|--> RRM1
    CTNNB1_gene --|"associated_with"|--> SQSTM1
    CTNNB1_gene --|"associated_with"|--> RAB7A
    
    CTNNB1_gene --|"regulates"|--> ALS
    CTNNB1_gene --|"therapeutic_target"|--> MS
    CTNNB1_gene --|"therapeutic_target"|--> neuroinflammation
    CTNNB1_gene --|"therapeutic_target"|--> fibrosis
    CTNNB1_gene --|"regulates"|--> cancer
    
    wnt_signaling --|"dysfunction_leads_to"|--> ALS
    cell_adhesion --|"impairment_causes"|--> neuroinflammation
    synaptic_function --|"disruption_in"|--> MS
    
    style beta_catenin fill:#006494
    style wnt_signaling fill:#1b5e20
    style cell_adhesion fill:#1b5e20
    style synaptic_function fill:#1b5e20
    style TCF3 fill:#4a1a6b
    style AXIN2 fill:#4a1a6b
    style LRP1 fill:#4a1a6b
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style neuroinflammation fill:#ef5350
    style cancer fill:#5d4400
    style fibrosis fill:#5d4400