entity

Familial ALS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Familial ALS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

5Analyses

0Outgoing

8Incoming

0Experiments

7Debates

No AI portrait yet

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (8)

Source	Relation	Type	Str
VCP	causes	gene	0.90
FUS	causes	protein	0.90
FUS mutations	causes	gene	0.90
C9orf72 Repeat Expansions	increases_risk	phenotype	0.90
TBK1 mutations	causes	gene	0.90
C9ORF72	increases_risk	gene	0.90
SOD1	risk_factor_for	gene	0.90
GPX4	biomarker_for	protein	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.680

What are the neuron-specific effects of ALS-causing mutations on autophagy machi

neurodegeneration | 2026-04-08 | 4 hypotheses Top: 0.720

What determines the specificity of RNA-protein interactions that drive distinct

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.712

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.717

TDP-43 phase separation therapeutics for ALS-FTD

neurodegeneration | 2026-04-01 | 18 hypotheses Top: 0.738

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (7)

Multi-agent debates referencing this entity

Debate: Liquid-to-Solid Transition Pathology Reveals Granule Weak Points

closed · Rounds: 4 · Score: 0.58 · 2026-04-27

The study shows TRIM21 and autophagy receptors can eliminate both physiological

closed · Rounds: 4 · Score: 0.75 · 2026-04-22

While the study identifies G3BP1 as a central node triggering phase separation,

closed · Rounds: 4 · Score: 0.76 · 2026-04-21

While ALS-causing mutations impair autophagy factors, the neuron-specific effect

closed · Rounds: 4 · Score: 0.81 · 2026-04-21

Ferroptosis in ALS and motor neuron disease: GPX4, lipid peroxidation, and iron

closed · Rounds: 5 · Score: 0.59 · 2026-04-16

TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small

closed · Rounds: 6 · Score: 0.84 · 2026-04-12

TDP-43 phase separation therapeutics for ALS-FTD

closed · Rounds: 4 · Score: 0.95 · 2026-04-11

Related Research

Hypotheses and analyses mentioning Familial ALS in their description or question text

No additional research found