gene

SOD1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2775Connections

0Hypotheses

7Analyses

50Outgoing

50Incoming

Summary

SOD1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with AD, ALS, ALZHEIMER'S DISEASE. Connected to 930 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SOD1
Full Name	Superoxide Dismutase 1
Chromosome	21q22.11
Protein Type	Enzyme
Function	is a copper/zinc-dependent enzyme that catalyzes the dismutation of superoxide radical (O₂⁻) into molecular oxygen (O₂) and hydrogen peroxide (H₂O₂).
Primary Expression	Motor cortex, Spinal cord, Widespread throughout CNS
Molecular Weight	16 kDa
Amino Acids	154 aa
Pathways	Amyloid, Apoptosis, Autophagy, Epigenetic, Er Stress
Ensembl ID	ENSG00000142168
GeneCards	SOD1
Human Protein Atlas	SOD1
Associated Diseases	AD, ALS, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, ARM, Aging
Known Drugs/Compounds	TOFERSEN, RAPAMYCIN, Lactiplantibacillus plantarum FRT4, Antisense Oligonucleotides, Tofersen, Amyloid-Beta Oligomers
Interactions	CALCINEURIN, ATG12, ATG10, GAIN, TNF, PLEKHG5
KG Connections	2095 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🧬 3D Structure: SOD1 — PDB 2C9V Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SOD1["SOD1"] -->|"causes"| ALS["ALS"]
    SOD1["SOD1"] -->|"causes"| FALS["FALS"]
    SOD1["SOD1"] -->|"associated"| AD["AD"]
    SOD1["SOD1"] -->|"associated"| ALS_1["ALS"]
    SOD1["SOD1"] -->|"encodes"| SOD1_protein["SOD1_protein"]
    SOD1["SOD1"] -->|"expressed in"| chromosome_21["chromosome_21"]
    STIP1["STIP1"] -->|"associated"| SOD1["SOD1"]
    LGALS3["LGALS3"] -->|"associated"| SOD1["SOD1"]
    HSPA8["HSPA8"] -->|"associated"| SOD1["SOD1"]
    MCOLN1["MCOLN1"] -->|"associated"| SOD1["SOD1"]
    style SOD1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1425)

Target	Relation	Type	Str
FALS	causes	disease	1.00
TARDBP	associated_with	gene	1.00
ALS	causes	disease	1.00
Als	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Amyotrophic Lateral Sclerosis	causes	disease	1.00
AMYOTROPHIC LATERAL SCLEROSIS	causes	gene	1.00
NEURON	associated_with	gene	1.00
DEMENTIA	associated_with	disease	1.00
TNF	associated_with	gene	0.98
superoxide anion	inhibits	phenotype	0.95
Familial Amyotrophic Lateral Sclerosis	risk_factor_for	disease	0.95
Lysosome-To-Mitochondria Communication	mediates	pathway	0.95
DNA Oxidative Damage	protects_against	process	0.95
Parkinson	therapeutic_target	disease	0.95
Inflammation	activates	disease	0.95
Amyotrophic Lateral Sclerosis	activates	disease	0.95
Amyotrophic Lateral Sclerosis	risk_factor_for	disease	0.95
Hypoglossal Nucleus	expressed_in	brain_region	0.92
miR-3960	upregulates	biomarker	0.90
Motor Neuron Degeneration	causes	disease	0.90
Motor Neuron Degeneration	contributes_to	process	0.90
Cell Senescence	inhibits	process	0.90
Superoxide Radicals	protects_against	compound	0.90
Brainstem	expressed_in	brain_region	0.90
Motor Neurons	expressed_in	cell_type	0.90
Familial ALS	risk_factor_for	disease	0.90
motor neuron death	contributes_to	process	0.90
Gain Of Function Mutations	involved_in	variant	0.90
amyotrophic lateral sclerosis	causes	disease	0.90
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.90
ALS	risk_factor_for	disease	0.90
oxidative stress	promotes	process	0.90
ALS	treats	disease	0.90
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.90
AMYOTROPHIC LATERAL SCLEROSIS	activates	gene	0.90
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.90
Axonal Degeneration	associated_with	process	0.88
neurodegeneration	contributes_to	process	0.88
Motor Neuron Loss	contributes_to	process	0.85
mitochondrial swelling	promotes	process	0.85
Motor Neuron Degeneration	involved_in	process	0.85
Motor Neuron Loss	involved_in	process	0.85
Mtdna Synthesis	regulates	process	0.85
Mitochondrial Damage	causes	process	0.85
DNA Damage	associated_with	process	0.85
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
Alzheimer	therapeutic_target	disease	0.85

Incoming (1350)

Source	Relation	Type	Str
NRF2	associated_with	gene	1.00
AMYLOID	associated_with	gene	1.00
ALS	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
HUD	regulates	gene	0.95
Tofersen	targets	drug	0.90
HUD	binds	protein	0.90
HUD	upregulates	protein	0.90
CHK2	phosphorylates	protein	0.90
Fisetin	upregulates	compound	0.90
Chlorogenic acid	upregulates	compound	0.90
NEUROINFLAMMATION	associated_with	gene	0.90
IL-6	associated_with	gene	0.90
MTORC1	phosphorylates	protein	0.90
h-47ab2be5	targets_gene	hypothesis	0.90
h-10b5bf6f	targets_gene	hypothesis	0.90
GENES	associated_with	gene	0.90
ALS	treats	disease	0.90
Antisense Oligonucleotides	targets	drug	0.85
Amyloid-Beta Oligomers	inhibits	compound	0.85
ATM/Chk2 Pathway	activates	pathway	0.85
ATR/Chk1 Pathway	activates	pathway	0.85
antisense oligonucleotides	inhibits	drug	0.85
RNA interference	inhibits	pathway	0.85
CRISPR/Cas9	targets	pathway	0.85
FUS	associated_with	gene	0.82
intermittent hypoxia	inhibits	phenotype	0.80
Lactiplantibacillus plantarum FRT4	activates	drug	0.80
NFE2L2	upstream_of	gene	0.80
P2X7 receptor	mediates_release_of	protein	0.80
amyloid-beta oligomers	dysregulates	compound	0.80
Oligonucleotides	targets	compound	0.80
C9ORF72	treats	gene	0.80
PARKINSON'S DISEASE	therapeutic_target	gene	0.80
ALS	therapeutic_target	gene	0.80
NEURODEGENERATION	therapeutic_target	gene	0.80
ASTROCYTE	activates	gene	0.80
116B	upregulates	compound	0.78
CASP3	interacts_with	protein	0.75
FGF21	co_expressed_with	protein	0.75
ALS	targets	gene	0.75
CASP3	associated_with	gene	0.74
AKT	associated_with	gene	0.74
AMPK	associated_with	gene	0.74
ALS	activates	disease	0.74
AUTOPHAGY	associated_with	gene	0.74
ALS	causes	gene	0.74
NF-KB	associated_with	protein	0.74
C9ORF72	associated_with	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (7)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SOD1

Understanding Entity Pages

Summary

Wiki Pages (21)

SOD1 Mutant Motor Neurons

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Pathway Diagram

Outgoing (1425)

Incoming (1350)

Targeting Hypotheses (0)

Mentioning Analyses (7)

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic clocks and biological aging in neurodegeneration

Synaptic pruning by microglia in early AD

TDP-43 phase separation therapeutics for ALS-FTD

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Related Papers (0)

SOD1

Understanding Entity Pages

Summary

Wiki Pages (21)

SOD1 Mutant Motor Neurons

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

nimodipine-als

Therapeutics

NPM1 Gene

neuroinflammation

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

HNRNPA2B1 Protein

ALS Failed Approaches Analysis

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

oxidative-stress-comparison

Blood-Brain Barrier Dysfunction in Neurodegeneration

Neurotrophin Signaling Pathways in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Pathway Diagram

Outgoing (1425)

Incoming (1350)

Targeting Hypotheses (0)

Mentioning Analyses (7)

CRISPR-based therapeutic approaches for neurodegenerative diseases

CRISPR-based therapeutic approaches for neurodegenerative diseases

Epigenetic clocks and biological aging in neurodegeneration

Synaptic pruning by microglia in early AD

TDP-43 phase separation therapeutics for ALS-FTD

Astrocyte reactivity subtypes in neurodegeneration

4R-tau strain-specific spreading patterns in PSP vs CBD

Related Papers (0)