GABA-B RECEPTOR

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABA-B RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

The metabotropic GABA-B receptor is a GPCR that mediates slow inhibitory neurotransmission; involved in epilepsy, addiction, and being explored for neurodegenerative diseases

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graph TD
    GABA["GABA"]
    LC3B["LC3B"]
    GABA -->|"regulates"| LC3B
    ALS["ALS"]
    GABA -->|"activates"| ALS
    MTORC1["MTORC1"]
    GABA -->|"activates"| MTORC1
    Epigenetic["Epigenetic"]
    GABA -->|"regulates"| Epigenetic
    RB1["RB1"]
    GABA -->|"interacts_with"| RB1
    Actin["Actin"]
    GABA -->|"interacts_with"| Actin
    Microglia["Microglia"]
    GABA -->|"expressed_in"| Microglia
    CTSD["CTSD"]
    GABA -->|"associated_with"| CTSD
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    GABA -->|"co_discussed"| FRONTOTEMPORAL_DEMENTIA
    PIK3C3["PIK3C3"]
    GABA -->|"regulates"| PIK3C3
    MICROGLIA["MICROGLIA"]
    GABA -->|"co_discussed"| MICROGLIA
    lysosome["lysosome"]
    GABA -->|"inhibits"| lysosome
    style GABA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style LC3B fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MTORC1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Epigenetic fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style RB1 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Actin fill:#4a1a6b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Microglia fill:#01579b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CTSD fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style FRONTOTEMPORAL_DEMENTIA fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0
    style PIK3C3 fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MICROGLIA fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style lysosome fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0