MAVS

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAVS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Mitochondrial Antiviral Signaling Protein - key adaptor in innate immunity and neurodegeneration

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flowchart TD
    MAVS["MAVS<br/>Mitochondrial Antiviral<br/>Signaling Protein"]
    MITO["Mitochondria<br/>Localization"]
    INNATE["Innate Immunity<br/>Pathway"]
    IMMUNE["Immune Response<br/>Activation"]
    AUTOPHAGY["Autophagy<br/>Pathway"]
    FIP200["FIP200<br/>Autophagy Initiator"]
    AMBRA1["AMBRA1<br/>Autophagy Regulator"]
    RIPK1["RIPK1<br/>Cell Death Regulator"]
    HMGB1["HMGB1<br/>Damage Signal"]
    MAPK["MAPK<br/>Signaling"]
    MTOR["mTOR<br/>Pathway"]
    OXPHOS["Oxidative<br/>Phosphorylation"]
    ALS["ALS<br/>Neurodegeneration"]
    MS["Multiple Sclerosis<br/>Neuroinflammation"]
    NEURO_DEATH["Neuronal<br/>Cell Death"]
    INFLAMMATION["Chronic<br/>Neuroinflammation"]
    
    MAVS --|"localizes to"|--> MITO
    MAVS --|"regulates"|--> INNATE
    MAVS --|"regulates"|--> IMMUNE
    MAVS --|"activates"|--> AUTOPHAGY
    MAVS --|"interacts with"|--> FIP200
    MAVS --|"interacts with"|--> AMBRA1
    MAVS --|"interacts with"|--> RIPK1
    MAVS --|"interacts with"|--> HMGB1
    MAVS --|"modulates"|--> MAPK
    MAVS --|"interacts with"|--> MTOR
    MAVS --|"affects"|--> OXPHOS
    
    INNATE --|"contributes to"|--> INFLAMMATION
    IMMUNE --|"leads to"|--> INFLAMMATION
    RIPK1 --|"promotes"|--> NEURO_DEATH
    HMGB1 --|"amplifies"|--> INFLAMMATION
    INFLAMMATION --|"drives"|--> ALS
    INFLAMMATION --|"drives"|--> MS
    NEURO_DEATH --|"results in"|--> ALS
    
    style MAVS fill:#006494
    style AUTOPHAGY fill:#1b5e20
    style FIP200 fill:#1b5e20
    style AMBRA1 fill:#1b5e20
    style INNATE fill:#4a1a6b
    style IMMUNE fill:#4a1a6b
    style RIPK1 fill:#4a1a6b
    style HMGB1 fill:#4a1a6b
    style MAPK fill:#4a1a6b
    style MTOR fill:#4a1a6b
    style NEURO_DEATH fill:#ef5350
    style INFLAMMATION fill:#ef5350
    style ALS fill:#5d4400
    style MS fill:#5d4400
    style MITO fill:#2a0e3a
    style OXPHOS fill:#2a0e3a