drug

rapamycin

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about rapamycin: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1408Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💊 Drug Info

Name	rapamycin
Summary	Clinical trial evaluating rapamycin (sirolimus) as a disease-modifying treatment for ALS through mTOR inhibition and autophagy enhancement
Key Genes/Proteins	MTOR, mTOR, ATG, MAP1LC3B, SQSTM1, MTORC1
Related Diseases	seizures
Related Pathways	autophagy

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Novel Therapy Index

idea · 10647 words

→

Pathway Diagram

graph TD
    rapamycin["rapamycin"] -.->|"inhibits"| MTOR["MTOR"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    rapamycin["rapamycin"] -->|"treats"| seizures["seizures"]
    style seizures fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    rapamycin["rapamycin"] -->|"activates"| autophagy["autophagy"]
    style autophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    rapamycin["rapamycin"] -->|"prevents"| aging["aging"]
    style aging fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    rapamycin["rapamycin"] -->|"activates"| MTORC1["MTORC1"]
    style MTORC1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    rapamycin["rapamycin"] -->|"activates"| MAP1LC3B["MAP1LC3B"]
    style MAP1LC3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    rapamycin["rapamycin"] -->|"activates"| ATG["ATG"]
    style ATG fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style rapamycin fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (665)

Target	Relation	Type	Str
MTOR	inhibits	gene	0.92
mTOR	inhibits	protein	0.90
seizures	treats	phenotype	0.90
autophagy	activates	pathway	0.90
aging	prevents	process	0.90
ATG	targets	gene	0.90
MAP1LC3B	targets	gene	0.90
MTOR	targets	gene	0.90
SQSTM1	targets	gene	0.90
MTORC1	targets	gene	0.90
LAMP1	targets	gene	0.90
RAS	targets	gene	0.90
PI3K	targets	gene	0.90
AKT	targets	gene	0.90
GABA	targets	gene	0.90
GABARAP	targets	gene	0.90
TFEB	targets	gene	0.90
LC3	targets	gene	0.90
GAPDH	targets	gene	0.90
BECN1	targets	gene	0.90
RNA	targets	gene	0.90
ULK1	targets	gene	0.90
MAP1LC3	targets	gene	0.90
AMPK	targets	gene	0.90
autophagy	upregulates	process	0.90
autophagy pathway	modulates	pathway	0.85
PARKIN	activates	gene	0.80
ACTB	targets	gene	0.80
RAB7A	targets	gene	0.80
CTSD	targets	gene	0.80
PIK3C3	targets	gene	0.80
NLR	targets	gene	0.80
DNA	targets	gene	0.80
STING1	targets	gene	0.80
RB1	targets	gene	0.80
RB1CC1	targets	gene	0.80
ROS	targets	gene	0.80
ALS	targets	gene	0.80
VAMP8	targets	gene	0.80
CREB	targets	gene	0.80
STX17	targets	gene	0.80
RUBCNL	targets	gene	0.80
LAMP2	targets	gene	0.80
ATG7	targets	gene	0.80
GFP	targets	gene	0.80
Alzheimer's Disease	treats	disease	0.75
MTORC1	inhibits	protein	0.72
stroke	treats	disease	0.70
RUBCN	targets	gene	0.70
ATP	targets	gene	0.70

Incoming (743)

Source	Relation	Type	Str
LAMP1	activates	gene	0.95
PI3K	activates	gene	0.95
AKT	activates	gene	0.95
BECN1	activates	gene	0.95
AMPK	activates	gene	0.95
LC3	activates	gene	0.95
P62	activates	gene	0.95
MTOR	therapeutic_target	gene	0.95
MTOR	regulates	gene	0.95
AUTOPHAGY	regulates	process	0.95
GAPDH	activates	gene	0.80
APOPTOSIS	activates	process	0.80
CTSD	activates	gene	0.65
MYC	activates	gene	0.65
MICRORNA REGULATION	activates	process	0.65
ALS	activates	disease	0.65
BCL2	activates	gene	0.65
CREB	activates	gene	0.65
P53	activates	gene	0.65
LAMP2	activates	gene	0.65
CANCER	activates	disease	0.65
MTOR	interacts_with	gene	0.65
MTOR	implicated_in	gene	0.65
ATP	regulates	gene	0.65
ISCHEMIA	regulates	disease	0.65
LAMP1	regulates	gene	0.65
NADH	regulates	gene	0.65
AKT	targets	gene	0.65
MLKL	targets	gene	0.65
OPTN	phosphorylates	gene	0.65
PI3K	phosphorylates	gene	0.65
ALS	interacts_with	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	disease	0.65
HUNTINGTON	interacts_with	disease	0.65
LAMP1	interacts_with	gene	0.65
MTOR	targets	gene	0.65
PARKIN	targets	gene	0.65
PARKINSON	targets	disease	0.65
CREB	interacts_with	gene	0.65
LC3	targets	gene	0.65
OPTN	targets	gene	0.65
P62	regulates	gene	0.65
LC3	regulates	gene	0.65
DEMENTIA	interacts_with	disease	0.65
FRONTOTEMPORAL DEMENTIA	interacts_with	disease	0.65
FTD	interacts_with	disease	0.65
NEURON	interacts_with	cell_type	0.65
PINK1	causes	gene	0.65
ALZHEIMER	expressed_in	disease	0.65
ATG7	expressed_in	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

rapamycin

Understanding Entity Pages

Wiki Pages (21)

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

PD Cure Roadmap

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism