Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HUNTINGTON: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HUNTINGTON is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with ALS, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 908 entities in the SciDEX knowledge graph.
| Gene Symbol | HUNTINGTON |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | RAPAMYCIN |
| Interactions | ATG12, CALCINEURIN, GENES, AGING, NEURODEGENERATION, ATG10 |
| KG Connections | 2350 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HUNTINGTON["HUNTINGTON"] -->|"associated"| LYSOSOME["LYSOSOME"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| SIRT1["SIRT1"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| ALS["ALS"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| Huntington["Huntington"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
HUNTINGTON["HUNTINGTON"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
ASTROCYTE["ASTROCYTE"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
AMPK["AMPK"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
APP["APP"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
BDNF["BDNF"] -->|"associated"| HUNTINGTON["HUNTINGTON"]
style HUNTINGTON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 1.00 |
| Huntington | associated_with | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 1.00 |
| Parkinson | associated_with | disease | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Alzheimer | causes | disease | 1.00 |
| Huntington | causes | disease | 1.00 |
| Amyotrophic Lateral Sclerosis | causes | disease | 1.00 |
| Parkinson | causes | disease | 1.00 |
| Neurodegeneration | regulates | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Huntington | regulates | disease | 1.00 |
| PARKINSON | associated_with | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| HUNTINGTON'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| ALZHEIMER | associated_with | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Huntington | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| NEURODEGENERATIVE DISORDERS | associated_with | gene | 1.00 |
| Als | implicated_in | disease | 1.00 |
| Neurodegeneration | implicated_in | disease | 1.00 |
| HUNTINGTON'S DISEASE | causes | gene | 1.00 |
| ALZHEIMER | implicated_in | gene | 1.00 |
| HUNTINGTON'S DISEASE | implicated_in | gene | 1.00 |
| Parkinson | implicated_in | disease | 1.00 |
| Huntington | implicated_in | disease | 1.00 |
| Alzheimer | implicated_in | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Aging | associated_with | disease | 1.00 |
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 1.00 |
| HUNTINGTON'S DISEASE | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| PARKINSON | regulates | gene | 1.00 |
| PARKINSON | causes | gene | 1.00 |
| Mtor | activates | pathway | 1.00 |
| PARKINSON | implicated_in | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | associated_with | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| AMYLOID | associated_with | protein | 1.00 |
| TAU | associated_with | protein | 1.00 |
| medium spiny neurons | causes_loss_of | cell_type | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| ASTROCYTES | associated_with | cell_type | 0.98 |
| AUTOPHAGY | associated_with | gene | 0.90 |
| BDNF | associated_with | gene | 0.82 |
| MTOR | associated_with | gene | 0.82 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.80 |
| NEURODEGENERATION | causes | gene | 0.80 |
| NEURODEGENERATION | inhibits | gene | 0.80 |
| NEURODEGENERATION | therapeutic_target | gene | 0.80 |
| ALZHEIMER'S DISEASE | activates | gene | 0.74 |
| ALS | activates | disease | 0.74 |
| TARDBP | associated_with | gene | 0.74 |
| NEURODEGENERATION | contributes_to | gene | 0.70 |
| NEURODEGENERATIVE DISORDERS | regulates | gene | 0.70 |
| AGING | activates | gene | 0.70 |
| APOPTOSIS | activates | gene | 0.70 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.70 |
| C9ORF72 | associated_with | gene | 0.70 |
| MITOPHAGY | therapeutic_target | gene | 0.70 |
| NEURODEGENERATION | treats | gene | 0.70 |
| CYP46A1 | implicated_in | gene | 0.70 |
| MITOPHAGY | associated_with | gene | 0.66 |
| PARKIN | associated_with | gene | 0.66 |
| ALZHEIMER'S DISEASE | regulates | gene | 0.66 |
| AUTOPHAGY | activates | gene | 0.66 |
| APOE | associated_with | gene | 0.66 |
| PARKINSON'S DISEASE | activates | gene | 0.66 |
| ASTROCYTE | associated_with | gene | 0.65 |
| AMPK | associated_with | gene | 0.65 |
| APP | associated_with | gene | 0.65 |
| GDNF | associated_with | gene | 0.65 |
| GFAP | associated_with | gene | 0.65 |
| HDAC3 | associated_with | gene | 0.65 |
| CYP46A1 | associated_with | gene | 0.65 |
| ALZHEIMER'S | activates | disease | 0.65 |
| AMYOTROPHIC LATERAL SCLEROSIS | accumulates_in | disease | 0.65 |
| ACHE | reduces | gene | 0.65 |
| BASAL GANGLIA | expressed_in | brain_region | 0.65 |
| AKT | associated_with | gene | 0.64 |
| ALS | co_discussed | gene | 0.60 |
| AUTOPHAGY | co_discussed | gene | 0.60 |
| BCL2 | co_discussed | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
neurodegeneration | 2026-04-02 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||