Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABRE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABRE encodes the epsilon subunit of GABA-A receptors, mediating inhibitory neurotransmission in the brain and implicated in epilepsy, neurodevelopment, and neurodegenerative diseases
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| Gene Symbol | GABRE |
| Full Name | GABA-A Receptor Epsilon Subunit |
| Aliases | GABA-A Receptor Subunit Epsilon |
| Chromosome | Xq28 |
| Primary Expression | specific brain regions and peripheral tissues, where it contributes to inhibitory signaling that regulates neuronal excitability, network synchronizat |
| Subcellular Localization | synaptic and extrasynaptic membranes |
| Molecular Weight | 56 kDa |
| Amino Acids | 506 aa |
| Exons | 12 |
| UniProt ID | [P18507](https://www.uniprot.org/uniprot/P18507) |
| Ensembl ID | ENSG00000111640 |
| GeneCards | GABRE |
| Human Protein Atlas | GABRE |
| Hippocampus | High expression in CA1-CA3 regions and dentate gyrus |
| Cortex | Moderate expression, particularly in layer V pyramidal neurons |
| Associated Diseases | Epilepsy, Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GABRE["GABRE"]
neurodegeneration["neurodegeneration"]
GABRE -->|"implicated_in"| neurodegeneration
style GABRE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
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Hypotheses and analyses mentioning GABRE in their description or question text
No additional research found