protein

GCLMPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GCLMPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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Summary

Gclm (Glutamate Cysteine Ligase Modifier Subunit) is a critical regulatory component in the glutathione biosynthesis pathway, playing a vital role in cellular antioxidant defense.

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🔬 Protein Info

Gene Symbol	GCLMPROTEIN
Full Name	Glutamate-Cysteine Ligase Modifier Subunit
Chromosome	1p22.1
Protein Family	GCL family
Function	is a critical regulatory component in the glutathione biosynthesis pathway, playing a vital role in cellular antioxidant defense.
Molecular Weight	31 kDa
Amino Acids	274 aa
UniProt ID	P48507
GeneCards	GCLMPROTEIN
Human Protein Atlas	GCLMPROTEIN
N-terminal domain	Interacts with GCLC (catalytic subunit)
Regulatory domain	Contains binding sites for glutathione feedback inhibition
Dimerization interface	Forms heterodimer with GCLC
Post-translational modification sites	Phosphorylation and oxidation affect function
Associated Diseases	Infection, Inflammation, Sepsis
Interactions	GCLC, NRF2
KG Connections	52 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GCLMPROTEIN — AlphaFold P48507 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GCLM (Glutamate-Cysteine Ligase Modifier Subunit)

protein · 666 words

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Pathway Diagram

graph TD
    GCLMPROTEIN["GCLMPROTEIN"]
    neurodegeneration["neurodegeneration"]
    GCLMPROTEIN -->|"implicated_in"| neurodegeneration
    style GCLMPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GCLMPROTEIN in their description or question text

No additional research found