gene

GID4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GID4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GID4 encodes a subunit of the GID ubiquitin ligase complex involved in protein degradation and metabolic regulation with implications for neurodegeneration

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🧬 Gene Info

Gene Symbol	GID4
Full Name	GLUT4 Degradation Protein
Chromosome	17p13.1
Protein Type	Ligase
Function	encodes a critical subunit of the GID (Glucose-Induced Degradation) ubiquitin ligase complex.
Primary Expression	various brain cell types:
Molecular Weight	38 kDa
Amino Acids	345 aa
Exons	12
UniProt ID	[Q9H7M0](https://www.uniprot.org/uniprot/Q9H7M0)
Ensembl ID	ENSG00000131023
OMIM	618002
GeneCards	GID4
Human Protein Atlas	GID4
N-terminal domain	Proline/glutamine-rich region involved in substrate recognition
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GID4 Gene

gene · 1790 words

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GID4 Protein

protein · 1119 words

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Pathway Diagram

graph TD
    GID4["GID4"]
    neurodegeneration["neurodegeneration"]
    GID4 -->|"implicated_in"| neurodegeneration
    style GID4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GID4 in their description or question text

No additional research found