protein

GP130PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GP130PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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Summary

GP130 (Glycoprotein 130, also known as IL6ST or IL-6 Signal Transducer) is a common signal-transducing receptor subunit used by multiple interleukin-6 family cytokines.

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🔬 Protein Info

Gene Symbol	GP130
Full Name	gp130 - IL-6 Signal Transducer
Protein Type	Protein
Subcellular Localization	Cell membrane, cytoplasm (after ligand binding)
UniProt ID	Search UniProt
GeneCards	GP130
Human Protein Atlas	GP130
Associated Diseases	ALS
Known Drugs/Compounds	sIL-11R and sIL-6R
Interactions	STAT3, JAK1, IL6
KG Connections	8 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GP130PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

gp130 Protein - IL-6 Signal Transducer

protein · 1014 words

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Pathway Diagram

graph TD
    GP130PROTEIN["GP130PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GP130PROTEIN -->|"implicated_in"| neurodegeneration
    style GP130PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity