protein

GP130PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GP130PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GP130 (Glycoprotein 130, also known as IL6ST or IL-6 Signal Transducer) is a common signal-transducing receptor subunit used by multiple interleukin-6 family cytokines.

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🔬 Protein Info

Gene Symbol	GP130PROTEIN
Full Name	gp130 - IL-6 Signal Transducer
Protein Type	Protein
Function	is a common signal-transducing receptor subunit used by multiple interleukin-6 family cytokines.
Subcellular Localization	Cell membrane, cytoplasm (after ligand binding) ; Protein Family : IL-6 rece
Molecular Weight	130 kDa
Amino Acids	917 aa
UniProt ID	Search UniProt
GeneCards	GP130PROTEIN
Human Protein Atlas	GP130PROTEIN
Common receptor subunit	Shared by 10+ cytokine receptors
Signal transducer	Essential for downstream signaling
Expression pattern	Ubiquitous with high expression in brain
Isoforms	Multiple splice variants exist
Associated Diseases	ALS
Known Drugs/Compounds	sIL-11R and sIL-6R
Interactions	IL6, JAK1, STAT3
KG Connections	8 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GP130PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

gp130 Protein - IL-6 Signal Transducer

protein · 1014 words

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Pathway Diagram

graph TD
    GP130PROTEIN["GP130PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GP130PROTEIN -->|"implicated_in"| neurodegeneration
    style GP130PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GP130PROTEIN in their description or question text

No additional research found