gene

IL6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2178Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

IL6 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with AD, ALS, AMI. Connected to 962 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL6
Full Name	Interleukin 6
Chromosome	7q21
Function	is an important component in the neurobiology of neurodegenerative diseases.
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Epigenetic
Ensembl ID	ENSG00000136244
GeneCards	IL6
Human Protein Atlas	IL6
Associated Diseases	AD, ALS, AMI, ATOPIC_DERMATITIS, AUTOIMMUNE_DISEASES, Aging
Known Drugs/Compounds	DUPILUMAB, ziltivekimab, IRN, Urolithin A, Andrographis paniculata, SQDS
Interactions	IL6R, SREBF1, PSEN2, A2M, DHCR24, HMGCR
KG Connections	2177 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    IL6(["IL6"])
    INFLAMMATION("INFLAMMATION")
    Als["Als"]
    Inflammation["Inflammation"]
    Cancer["Cancer"]
    CANCER(["CANCER"])
    GENES(["GENES"])
    IL_6(["IL-6"])
    TNF(["TNF"])
    AKT1(["AKT1"])
    Tumor["Tumor"]
    Infection["Infection"]
    T_Cell_Differentiation("T Cell Differentiation")

    IL6 -->|"activates"| INFLAMMATION
    IL6 -->|"therapeutic target"| Als
    IL6 -.->|"inhibits"| Inflammation
    IL6 -->|"activates"| Cancer
    IL6 -->|"activates"| Inflammation
    IL6 -->|"activates"| CANCER
    IL6 -->|"therapeutic target"| GENES
    IL6 -->|"activates"| IL_6
    TNF -->|"activates"| IL6
    TNF -->|"therapeutic target"| IL6
    AKT1 -->|"therapeutic target"| IL6
    IL6 -->|"activates"| Als
    IL6 -->|"associated with"| Tumor
    IL6 -->|"activates"| Infection
    IL6 -->|"regulates"| T_Cell_Differentiation

    style IL6 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1347)

Target	Relation	Type	Str
INFLAMMATION	activates	phenotype	1.00
Als	therapeutic_target	disease	1.00
Inflammation	inhibits	disease	1.00
Cancer	activates	disease	1.00
Inflammation	activates	disease	1.00
CANCER	activates	gene	1.00
GENES	therapeutic_target	gene	1.00
IL-6	activates	gene	1.00
T Cell Differentiation	regulates	process	0.95
Th17 Cell	activates	cell_type	0.95
Frailty	biomarker_for	phenotype	0.95
Als	activates	disease	0.95
Tumor	associated_with	disease	0.95
Infection	activates	disease	0.95
STAT3	activates	protein	0.90
ST6GAL1	contributes_to	gene	0.90
JAK/STAT3 pathway	activates	pathway	0.90
pituitary tumor cell growth	activates	phenotype	0.90
normal pituitary cell proliferation	inhibits	phenotype	0.90
Apathy	mediates	phenotype	0.90
Mesolimbic Dopamine	downregulates	process	0.90
STAT3	interacts_with	protein	0.90
Endotoxemia	associated_with	disease	0.90
Neuroinflammation	mediates	process	0.90
NEUROMYELITIS OPTICA SPECTRUM DISORDER	therapeutic_target	entity	0.90
Neurodegeneration	contributes_to	process	0.90
oxidative stress response	participates_in	pathway	0.90
Parkinson's Disease	promotes	disease	0.90
JAK	activates	protein	0.87
Chronic Obstructive Pulmonary Disease	associated_with	disease	0.85
Inhibitory Synapse Phenotypes	activates	phenotype	0.85
POEMS Syndrome	involved_in	disease	0.85
Recurrent Stroke	biomarker_for	disease	0.85
neuroinflammation	promotes	process	0.85
chronic inflammation	drives	pathway	0.85
inflammatory response	mediates	process	0.85
Neuromyelitis Optica Spectrum Disorder	contributes_to	disease	0.85
kidney inflammation	mediates	process	0.85
Insomnia	therapeutic_target	disease	0.85
Vascular Dysfunction	promotes	phenotype	0.85
Tumor	activates	disease	0.85
Cancer	inhibits	disease	0.85
Als	associated_with	disease	0.85
Neuroinflammation	activates	disease	0.85
Tumor	inhibits	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Atherosclerosis	therapeutic_target	disease	0.85
Inflammation	associated_with	disease	0.85
Carcinoma	associated_with	disease	0.85
Cancer	associated_with	disease	0.85

Incoming (831)

Source	Relation	Type	Str
TNF	activates	gene	1.00
TNF	therapeutic_target	gene	1.00
AKT1	therapeutic_target	gene	1.00
Anti-IL6 Antibody	targets	drug	0.95
IPA	downregulates	compound	0.95
Lapiferin	downregulates	compound	0.92
Urolithin A	inhibits	drug	0.90
NF-kB	regulates	pathway	0.90
rutin	inhibits	drug	0.90
Ric	downregulates	process	0.90
Betulinic Acid	downregulates	compound	0.90
Itaconate	downregulates	compound	0.90
Gallic Acid	downregulates	compound	0.90
Hearing Loss	upregulates	phenotype	0.90
Pulmonary Vascular Endothelial Cell Senescence	upregulates	process	0.90
NFKB1	activates	gene	0.90
high glucose	upregulates	compound	0.90
NRF2	regulates	gene	0.90
DTG	upregulates	entity	0.90
Microglia	upregulates	cell_type	0.90
ASTROCYTES	activates	cell_type	0.90
microglia	upregulates	cell_type	0.90
h-6f1e8d32	targets_gene	hypothesis	0.90
STAT3	activates	gene	0.90
NF-κB Signaling	upregulates	pathway	0.88
Microglia	expressed_in	cell_type	0.88
Dolutegravir	upregulates	drug	0.87
Rotenone	upregulates	compound	0.85
STAT3	phosphorylates	entity	0.85
Brainstem-To-Basal Ganglia Circuit	involved_in	mechanism	0.85
Palmitoleic Acid	downregulates	compound	0.85
PI3K-Akt signaling pathway	regulates	pathway	0.85
KCNK2	downregulates	gene	0.85
Influenza A Virus	upregulates	disease	0.85
GPR37	upregulates	gene	0.85
Ponicidin	downregulates	compound	0.85
Glucose	upregulates	compound	0.85
Leucocyanidin	downregulates	compound	0.85
SOCS3	inhibits	protein	0.85
Vinpocetine	downregulates	drug	0.85
ER STRESS	mediates	entity	0.85
Cachexia	upregulates	disease	0.85
IL17	upregulates	pathway	0.85
Andrographis paniculata	inhibits	drug	0.80
rs13306436	modifies	gene	0.80
SQDS	inhibits	drug	0.80
IL35	regulates	protein	0.80
GNAI1	inhibits	gene	0.80
GNAI3	inhibits	gene	0.80
AKT1	targets	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL6

Understanding Entity Pages

Summary

Wiki Pages (21)

IL6 (Redirect)

Microglial Cells — Cell Type Hierarchy

Epigenetic Alterations in Alzheimer's Disease

Cellular Senescence in Neurodegeneration

Psychobiotic Therapy for Neurodegenerative Diseases

Neuroinflammation in Parkinson's Disease

Cellular Senescence in Neurodegeneration

TNF Signaling Pathway in Neurodegeneration

Astrocyte Senescence Pathway in Neurodegeneration

move-brain-pd-nct07299279

USH2A Protein

neuroinflammation-ad-pd-als

setd1a

IL-1α Protein

Cellular Senescence Hypothesis in Parkinson's Disease

TREM2 in ALS

GAB2 — GRB2 Associated Binding Protein 2

Neuroinflammatory Cytokine Storm in Neurodegeneration

PSAP-GPR37-IL-6 Axis in Parkinson's Disease

Post-Acute Viral Reservoir Hypothesis in Parkinson's Disease