gene

JAK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JAK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

359Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

JAK1 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, biomarker for. Associated with ALS, Aging, Als. Connected to 188 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JAK1
Full Name	Janus Kinase 1
Chromosome	1p31.3
Function	JAK1 encodes Janus kinase 1, a non-receptor tyrosine kinase that mediates signaling for type I and type II cytokine receptors.
Primary Expression	most cell types
Pathways	JAK-STAT pathway
UniProt ID	[P23458](https://www.uniprot.org/uniprot/P23458)
Ensembl ID	ENSG00000162433
OMIM	147795
GeneCards	JAK1
Human Protein Atlas	JAK1
Associated Diseases	Alzheimer, Alzheimer'S Disease, Huntington, Huntington's disease, Tumor
Known Drugs/Compounds	quercetin, Ponicidin
Interactions	IL6, HIF1A, STAT1, CXCL10, STING, TNF
KG Connections	359 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JAK1["JAK1"] -->|"activates"| STAT3["STAT3"]
    JAK1["JAK1"] -.->|"inhibits"| Aging["Aging"]
    JAK1["JAK1"] -->|"activates"| Ms["Ms"]
    JAK1["JAK1"] -.->|"inhibits"| Inflammation["Inflammation"]
    JAK1["JAK1"] -->|"regulates"| Inflammation_1["Inflammation"]
    JAK1["JAK1"] -->|"biomarker for"| Als["Als"]
    LIFR["LIFR"] -->|"activates"| JAK1["JAK1"]
    GP130["GP130"] -->|"activates"| JAK1["JAK1"]
    HIF1A["HIF1A"] -->|"activates"| JAK1["JAK1"]
    IL6["IL6"] -.->|"inhibits"| JAK1["JAK1"]
    style JAK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (226)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
STAT3	activates	protein	0.90
Inflammation	inhibits	disease	0.85
Tumor	activates	disease	0.85
STAT1	phosphorylates	protein	0.85
STAT3	phosphorylates	gene	0.80
Lupus	activates	disease	0.75
Autoimmune	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Carcinoma	activates	disease	0.75
Metastasis	activates	pathway	0.70
JAK-STAT signaling	participates_in	pathway	0.70
MAPK signaling	participates_in	pathway	0.70
Aging	inhibits	disease	0.65
Ms	activates	disease	0.65
Inflammation	regulates	disease	0.65
Als	biomarker_for	disease	0.65
Atherosclerosis	regulates	disease	0.65
Ms	biomarker_for	disease	0.65
Fibrosis	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	inhibits	disease	0.65
Neuroinflammation	activates	disease	0.65
Diabetes	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Tumor	associated_with	disease	0.65
ALS	biomarker_for	disease	0.65
Als	contributes_to	disease	0.65
Psoriasis	contributes_to	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Psoriasis	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Infection	activates	disease	0.65
Ischemia	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Lymphoma	activates	disease	0.65
Autoimmune	inhibits	disease	0.65
Leukemia	inhibits	disease	0.65
Diabetes	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ferroptosis	activates	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65

Incoming (133)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	0.90
RIPK1	interacts_with	gene	0.88
NLRP3	interacts_with	gene	0.85
LIFR	activates	protein	0.80
Ponicidin	inhibits	compound	0.80
STAT1	activates	gene	0.80
JAK	inhibits	gene	0.70
CANCER	therapeutic_target	gene	0.70
GP130	activates	protein	0.64
HIF1A	activates	gene	0.60
IL6	inhibits	gene	0.60
NR4A2	biomarker_for	gene	0.60
CXCL2	biomarker_for	gene	0.60
CSF2	biomarker_for	gene	0.60
STAT3	regulates	gene	0.60
MMP9	biomarker_for	gene	0.60
IL1A	biomarker_for	gene	0.60
HTR3C	biomarker_for	gene	0.60
NTS	biomarker_for	gene	0.60
LDLR	biomarker_for	gene	0.60
JAK3	expressed_in	gene	0.60
GAIN	expressed_in	gene	0.60
STAT1	expressed_in	gene	0.60
STAT6	expressed_in	gene	0.60
TNF	activates	gene	0.60
STAT6	biomarker_for	gene	0.60
CD4	activates	gene	0.60
TNF	contributes_to	gene	0.60
PI3K	contributes_to	gene	0.60
CD14	contributes_to	gene	0.60
CXCL10	activates	gene	0.60
AKT	contributes_to	gene	0.60
CXCR3	contributes_to	gene	0.60
ATG5	activates	gene	0.60
SQSTM1	activates	gene	0.60
SOCS1	activates	gene	0.60
CEBPB	activates	gene	0.60
P62	activates	gene	0.60
MCL1	expressed_in	gene	0.60
SOCS3	regulates	gene	0.60
STAT3	expressed_in	gene	0.60
JAK2	regulates	gene	0.60
BCL2	expressed_in	gene	0.60
STAT3	inhibits	gene	0.60
TLR3	therapeutic_target	gene	0.60
PRMT5	therapeutic_target	gene	0.60
UBIQUITIN	activates	gene	0.60
EGFR	activates	gene	0.60
AKT	activates	gene	0.60
STAT3	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

JAK1

Understanding Entity Pages

Summary

Wiki Pages (21)

JAK1 — Janus Kinase 1

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

Cellular Senescence in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

JAK-STAT Signaling Pathway in Neurodegeneration

IL28B (Interleukin 28B)

CNTFR Gene

DNA Sensing Pathways in Neurodegeneration

Interferon Signaling in Neurodegeneration

IL27 — Interleukin 27

Section 187: Advanced Cytokine and Chemokine Network Therapy in CBS/PSP

IL-10 Protein

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

KIF18A Gene — Kinesin Family Member 18A

Section 135: Telomere Biology and Anti-Aging Interventions in CBS/PSP

IL13 — Interleukin 13

Cellular Senescence Therapeutic Targeting