gene

GRK5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRK5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

4Outgoing

4Incoming

0Experiments

Summary

G protein-coupled receptor kinase 5 (GRK5) - calcium/calmodulin-dependent kinase with roles in muscarinic receptor signaling, Alzheimer's disease, and cardiovascular function.

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🧬 Gene Info

Gene Symbol	GRK5
Full Name	G Protein-Coupled Receptor Kinase 5
Aliases	G protein-coupled receptor kinase 5 (GRK5)
Chromosome	10q26.11
Protein Family	GRK family (Ca²⁺/CaM-dependent)
Protein Type	Kinase
Function	M4 (CHRM4) — Gi-coupled receptor in striatum and cortex; GRK5 modulates dopaminergic-GABAergic interactions.
Molecular Weight	64 kDa
Amino Acids	566 aa
UniProt ID	[P34947](https://www.uniprot.org/uniprot/P34947)
Ensembl ID	ENSG00000198829
OMIM	602314
GeneCards	GRK5
Human Protein Atlas	GRK5
M2 (CHRM2)	Gi-coupled receptor regulating heart rate and cognition; GRK5 phosphorylation promotes desensitization.
Associated Diseases	neurodegeneration
Interactions	Proteins, GRK2, AND, CANCER
KG Connections	8 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    GRK5(["GRK5"])
    Cancer["Cancer"]
    App(["App"])
    GRK2(["GRK2"])
    AND(["AND"])
    CANCER(["CANCER"])
    Proteins(["Proteins"])
    neurodegeneration["neurodegeneration"]

    GRK5 -->|"therapeutic target"| Cancer
    GRK5 -->|"activates"| Cancer
    GRK5 -->|"therapeutic target"| App
    GRK2 -->|"activates"| GRK5
    AND -->|"activates"| GRK5
    CANCER -->|"activates"| GRK5
    GRK5 -->|"activates"| Proteins
    GRK5 -->|"implicated in"| neurodegeneration

    style GRK5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
App	therapeutic_target	protein	0.60
Proteins	activates	protein	0.50

Incoming (4)

Source	Relation	Type	Str
GRK2	activates	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
GRK2	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GRK5

Understanding Entity Pages

Summary

Wiki Pages (11)

GRK5 — G Protein-Coupled Receptor Kinase 5

CSNK1D - Casein Kinase 1 Delta

GRK6 Gene

GRK3 — G Protein-Coupled Receptor Kinase 3

Phosphorylated Alpha-Synuclein (pSer129) - Biomarker

Alpha-Synuclein Phosphorylation Mechanisms

ARRB1 — Arrestin Beta 1

GRK2 — G Protein-Coupled Receptor Kinase 2

GRK5 Protein — G Protein-Coupled Receptor Kinase 5

Proteins