| Gene Symbol | GRK5 |
| Full Name | G Protein-Coupled Receptor Kinase 5 |
| Aliases | G protein-coupled receptor kinase 5 (GRK5) |
| Chromosome | 10q26.11 |
| Protein Family | GRK family (Ca²⁺/CaM-dependent) |
| Protein Type | Kinase |
| Function | M4 (CHRM4) — Gi-coupled receptor in striatum and cortex; GRK5 modulates dopaminergic-GABAergic interactions. |
| Molecular Weight | 64 kDa |
| Amino Acids | 566 aa |
| UniProt ID | [P34947](https://www.uniprot.org/uniprot/P34947) |
| Ensembl ID | ENSG00000198829 |
| OMIM | 602314 |
| GeneCards | GRK5 |
| Human Protein Atlas | GRK5 |
| M2 (CHRM2) | Gi-coupled receptor regulating heart rate and cognition; GRK5 phosphorylation promotes desensitization. |
| Associated Diseases | neurodegeneration |
| Interactions | CANCER, GRK2, Proteins |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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