Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Proteins: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | Proteins |
| Associated Diseases | Cognitive Decline |
| Interactions | MAP2, MAP1B, MAP6, NUDEL, DYNEIN, LIS1 |
| KG Connections | 1210 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
Proteins["Proteins"] -->|"involved in"| Age_Related_Disease_Risk["Age-Related Disease Risk"]
style Age_Related_Disease_Risk fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Proteins["Proteins"] -->|"references"| SIRT6["SIRT6"]
style SIRT6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Proteins["Proteins"] -->|"references"| MMP2["MMP2"]
style MMP2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Proteins["Proteins"] -->|"references"| PYCARD["PYCARD"]
style PYCARD fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Proteins["Proteins"] -->|"references"| HNRNPA2B1["HNRNPA2B1"]
style HNRNPA2B1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Proteins["Proteins"] -->|"references"| AQP4["AQP4"]
style AQP4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Proteins["Proteins"] -->|"references"| COX4I1["COX4I1"]
style COX4I1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Reactive_Oxygen_Species["Reactive Oxygen Species"] -->|"associated"| Proteins["Proteins"]
style Reactive_Oxygen_Species fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style Proteins fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Age-Related Disease Risk | involved_in | phenotype | 0.90 |
| Mortality Risk | risk_factor_for | phenotype | 0.85 |
| Disease Risk | risk_factor_for | phenotype | 0.85 |
| Prostate Cancer Biomarkers | associated_with | biomarker | 0.80 |
| WNT SIGNALING | inhibits | concept | 0.50 |
| PD-L1 | inhibits | concept | 0.50 |
| AMYLOID-β | interacts_with | concept | 0.50 |
| STRESS GRANULES | associated_with | concept | 0.50 |
| STRESS GRANULES | activates | concept | 0.50 |
| α-SYNUCLEIN | interacts_with | concept | 0.50 |
| GSK3 | activates | concept | 0.50 |
| PI3K/AKT SIGNALING | activates | concept | 0.50 |
| PEROXISOME | activates | concept | 0.50 |
| CHAPERONE-MEDIATED AUTOPHAGY | interacts_with | concept | 0.50 |
| AUTOPHAGOSOME | associated_with | concept | 0.50 |
| RAPAMYCIN | activates | concept | 0.50 |
| CHAPERONE-MEDIATED AUTOPHAGY | activates | concept | 0.50 |
| AUTOPHAGOSOME | regulates | concept | 0.50 |
| AUTOPHAGOSOME | inhibits | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | associated_with | concept | 0.50 |
| AUTOPHAGOSOME | activates | concept | 0.50 |
| AUTOPHAGOSOME | interacts_with | concept | 0.50 |
| ENDOPLASMIC RETICULUM STRESS | activates | concept | 0.50 |
| ENDOPLASMIC RETICULUM | activates | concept | 0.50 |
| SELECTIVE AUTOPHAGY | associated_with | concept | 0.50 |
| SELECTIVE AUTOPHAGY | activates | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | interacts_with | concept | 0.50 |
| CX43 | expressed_in | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | expressed_in | concept | 0.50 |
| ENDOPLASMIC RETICULUM | associated_with | concept | 0.50 |
| GENE EXPRESSION | interacts_with | concept | 0.50 |
| B CELLS | interacts_with | concept | 0.50 |
| FIBROBLASTS | activates | concept | 0.50 |
| ENDOPLASMIC RETICULUM | regulates | concept | 0.50 |
| GENE EXPRESSION | activates | concept | 0.50 |
| ISCHEMIC STROKE | expressed_in | concept | 0.50 |
| METFORMIN | associated_with | concept | 0.50 |
| B CELLS | inhibits | concept | 0.50 |
| CEREBROSPINAL FLUID | interacts_with | concept | 0.50 |
| METFORMIN | inhibits | concept | 0.50 |
| GLIOSIS | activates | concept | 0.50 |
| GENE EXPRESSION | inhibits | concept | 0.50 |
| Neuroprotection | activates | process | 0.50 |
| α-SYNUCLEIN | activates | concept | 0.50 |
| LEWY BODY | inhibits | concept | 0.50 |
| AMYGDALA | associated_with | concept | 0.50 |
| AMYGDALA | activates | concept | 0.50 |
| CENTRAL NERVOUS SYSTEM | regulates | concept | 0.50 |
| ENDOTHELIAL CELLS | activates | concept | 0.50 |
| SELECTIVE AUTOPHAGY | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAP2 | interacts_with | gene | 0.50 |
| MAP1B | interacts_with | gene | 0.50 |
| MAP6 | interacts_with | gene | 0.50 |
| MAP6 | regulates | gene | 0.50 |
| Neuron | interacts_with | cell_type | 0.50 |
| MICROTUBULES | interacts_with | concept | 0.50 |
| Neuron | associated_with | cell_type | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| GLUT4 | activates | concept | 0.50 |
| INSULIN | activates | concept | 0.50 |
| NUDEL | interacts_with | protein | 0.50 |
| DYNEIN | interacts_with | protein | 0.50 |
| LIS1 | interacts_with | protein | 0.50 |
| IDH1 | associated_with | gene | 0.50 |
| Glioma | associated_with | disease | 0.50 |
| TERT | inhibits | gene | 0.50 |
| IDH1 | inhibits | gene | 0.50 |
| MCL1 | inhibits | gene | 0.50 |
| VEGFA | inhibits | protein | 0.50 |
| MDM4 | inhibits | gene | 0.50 |
| Immune Checkpoint | inhibits | pathway | 0.50 |
| COMPLEMENT | interacts_with | pathway | 0.50 |
| TUMOR | inhibits | disease | 0.50 |
| HSPG2 | inhibits | concept | 0.50 |
| ALZHEIMER | interacts_with | gene | 0.50 |
| disease | interacts_with | disease | 0.50 |
| ALZHEIMER'S | interacts_with | concept | 0.50 |
| APOE | interacts_with | gene | 0.50 |
| NTN1 | interacts_with | gene | 0.50 |
| GPNMB | interacts_with | protein | 0.50 |
| NPTX2 | interacts_with | protein | 0.50 |
| disease | associated_with | disease | 0.50 |
| AMYLOID | regulates | gene | 0.50 |
| Endocytosis | regulates | pathway | 0.50 |
| Exocytosis | regulates | pathway | 0.50 |
| TARDBP | interacts_with | gene | 0.50 |
| SNRNP70 | interacts_with | gene | 0.50 |
| NTN3 | interacts_with | gene | 0.50 |
| AMYLOID | interacts_with | gene | 0.50 |
| DIABETES | associated_with | disease | 0.50 |
| Type 2 Diabetes | associated_with | disease | 0.50 |
| DIABETES | interacts_with | disease | 0.50 |
| Type 2 Diabetes | interacts_with | disease | 0.50 |
| DIABETES | activates | disease | 0.50 |
| HEAT SHOCK PROTEINS | associated_with | protein | 0.50 |
| Chaperone | protects_against | pathway | 0.50 |
| cancer | activates | disease | 0.50 |
| disease | activates | disease | 0.50 |
| TGM2 | expressed_in | gene | 0.50 |
| SDC1 | expressed_in | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m | 0.348 | neurodegeneration | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.559
neurodegeneration | 2026-04-12 | 0 hypotheses
molecular biology | 2026-04-10 | 0 hypotheses
neurodegeneration | 2026-04-08 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745] | Rydzanicz M, Jagła M, Kosinska J, Tomasi | Clin Genet | 2017 | 1 |
| TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375] | van Spronsen M, Mikhaylova M, Lipka J, S | Neuron | 2013 | 1 |
| Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670] | Randall TS, Moores C, Stephenson FA | FEBS Lett | 2013 | 1 |
| Therapeutic developments in pancreatic cancer. [PMID:37798442] | ["Hu Z", "O'Reilly E"] | Nature reviews. Gastroenterolo | 2024 | 0 |
| Defining treatment-resistant depression. [PMID:31638723] | ["Gaynes B", "Lux L", "Gartlehner G", "A | Depression and anxiety | 2020 | 0 |
| Emerging trends in global freshwater availability. [PMID:29769728] | ["Rodell M", "Famiglietti J", "Wiese D", | Nature | 2018 | 0 |
| Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969] | ["Kurmani S", "Squire I"] | Current heart failure reports | 2017 | 0 |
| Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335] | ["Aquino R", "Vasques P", "Cavalcante D" | Revista do Colegio Brasileiro | 2017 | 0 |
| The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062] | ["Kane J", "Johnson R", "Robinson C", "J | The Journal of adolescent heal | 2016 | 0 |
| A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607] | ["Naqvi N", "Li M", "Calvert J", "Tejada | Cell | 2014 | 0 |
| Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899] | ["Pivac N", "Knezevi\u0107 A", "Gornik O | Molecular & cellular proteomic | 2011 | 0 |
| The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503] | ["Bulgakova N", "Knust E"] | Journal of cell science | 2009 | 0 |
| CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423] | ["Landsman L", "Bar-On L", "Zernecke A", | Blood | 2009 | 0 |
| GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324] | Brickley K, Smith MJ, Beck M, Stephenson | The Journal of biological chem | 2005 | 0 |