gene

GRM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

8Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for grm1 Gene

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🧬 Gene Info

Gene Symbol	GRM1
Full Name	Glutamate Metabotropic Receptor 1
Chromosome	11q14.2
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	cerebellar Purkinje cells where it is essential for motor learning, and is also expressed in other brain regions including the hippocampus, basal gang
Molecular Weight	150 kDa
Pathways	MAPK signaling, cascade: ### Signal Transduction Pathway
UniProt ID	Q9ULM0
NCBI Gene ID	2917
Ensembl ID	ENSG00000168385
OMIM	604473
GeneCards	GRM1
Human Protein Atlas	GRM1
Gq coupling	Activates phospholipase C (PLC) pathway
Associated Diseases	neurodegeneration
Interactions	MTOR
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GRM1 — AlphaFold Q9ULM0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    GRM1(["GRM1"])
    CCR8(["CCR8"])
    P2RY13(["P2RY13"])
    ADCY2(["ADCY2"])
    CYTOKINES(["CYTOKINES"])
    App(["App"])
    neurodegeneration["neurodegeneration"]

    GRM1 -->|"regulates"| CCR8
    GRM1 -->|"regulates"| P2RY13
    GRM1 -->|"regulates"| ADCY2
    GRM1 -->|"expressed in"| CYTOKINES
    GRM1 -->|"expressed in"| App
    GRM1 -->|"implicated in"| neurodegeneration

    style GRM1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (8)

Target	Relation	Type	Str
protein synthesis	upregulates	process	0.90
MTOR	activates	gene	0.90
APOE	protects_against	gene	0.85
CCR8	regulates	gene	0.60
P2RY13	regulates	gene	0.60
ADCY2	regulates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
App	expressed_in	protein	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity