Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adcy2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADCY2 |
| Full Name | Adenylate cyclase 2 (Membrane-bound adenylyl cyclase) |
| Aliases | Adenylate Cyclase 2 |
| Chromosome | 5p15.2 |
| Protein Type | Enzyme |
| Function | is a membrane-bound enzyme that catalyzes the conversion of ATP to cyclic adenosine monophosphate (cAMP), a crucial second messenger in cellular signaling. |
| Molecular Weight | 125 kDa |
| UniProt ID | [Q08462](https://www.uniprot.org/uniprot/Q08462) |
| Ensembl ID | ENSG00000045081 |
| OMIM | 103070 |
| GeneCards | ADCY2 |
| Human Protein Atlas | ADCY2 |
| Associated Diseases | Alzheimer's disease (AD |
| Interactions | MTNR1A, CNR2, CCR5, CXCL8, C3AR1, GRM2 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ADCY2["ADCY2"]
ADCY2 -->|"interacts"| Alzheimer["Alzheimer"]
ADCY2 -->|"interacts"| Als["Als"]
ADCY2 -->|"interacts"| ALS["ALS"]
ADCY2 -->|"interacts"| ALZHEIMER["ALZHEIMER"]
ADCY2 -->|"expressed in"| CYTOKINES["CYTOKINES"]
ADCY2 -->|"expressed in"| App["App"]
ADCY2 -->|"interacts"| MTNR1A["MTNR1A"]
ADCY2 -->|"interacts"| CNR2["CNR2"]
ALZHEIMER -->|"interacts"| ADCY2
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| ADCY2
GRM1["GRM1"] -->|"regulates"| ADCY2
CCR8["CCR8"] -->|"regulates"| ADCY2
P2RY13["P2RY13"] -->|"regulates"| ADCY2| Source | Relation | Type | Str |
|---|---|---|---|
| CXCL12 | associated_with | gene | 0.60 |
| MTNR1A | associated_with | gene | 0.60 |
| NPY | associated_with | gene | 0.60 |
| C3AR1 | associated_with | gene | 0.60 |
| CCR5 | associated_with | gene | 0.60 |
| CXCL8 | associated_with | gene | 0.60 |
| CNR2 | associated_with | gene | 0.60 |
| GRM2 | associated_with | gene | 0.60 |
| GRM1 | regulates | gene | 0.60 |
| CCR8 | regulates | gene | 0.60 |
| P2RY13 | regulates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| ALZHEIMER | interacts_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | interacts_with | gene | 0.60 |
| HUB GENES | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADCY2 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||