gene

GTF2H2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GTF2H2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

GTF2H2 encodes the core XPB helicase subunit of the TFIIH transcription/repair complex, essential for nucleotide excision repair and transcription initiation. Linked to neurodegenerative diseases including Alzheimer's, Parkinson's, and xeroderma pigmentosum.

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🧬 Gene Info

Gene Symbol	GTF2H2
Aliases	General Transcription Factor IIH subunit 2
Chromosome	5q13.2
Function	is a component of the XPB (ERCC3)-containing core TFIIH subcomplex.
Primary Expression	Ubiquitous; high in brain, testis, thymus
Molecular Weight	44 kDa
Amino Acids	395 aa
UniProt ID	Q13887
NCBI Gene ID	2966
GeneCards	GTF2H2
Human Protein Atlas	GTF2H2
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GTF2H2 — AlphaFold Q13887 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GTF2H2 Gene

gene · 1688 words

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GTF2H2 Protein

protein · 1944 words

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Pathway Diagram

graph TD
    GTF2H2["GTF2H2"]
    neurodegeneration["neurodegeneration"]
    GTF2H2 -->|"implicated in"| neurodegeneration
    Alzheimer_S{"Alzheimer'S"}
    GTF2H2 -->|"implicated in"| Alzheimer_S
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    GTF2H2 -->|"implicated in"| Neurodegenerative_Diseases
    Parkinson_S{"Parkinson'S"}
    GTF2H2 -->|"implicated in"| Parkinson_S
    Transcription(["Transcription"])
    GTF2H2 -->|"regulates"| Transcription
    style GTF2H2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
    style Neurodegenerative_Diseases fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Alzheimer_S fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Parkinson_S fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Transcription fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GTF2H2 in their description or question text

No additional research found