Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Gut: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Fat Absorption | involved_in | process | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Brain | mediates | cell_type | 0.90 |
| Brain-to-Gut Signal | mediates | mechanism | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam | 0.617 | neurodegeneration | What are the mechanisms by which gut mic |
| Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming | 0.607 | neurodegeneration | What are the mechanisms by which gut mic |
| H7: Enteric Nervous System Alpha-Synuclein Propagation Block | 0.595 | neurodegeneration | How does engineered C. butyricum cross t |
| Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A | 0.512 | neurodegeneration | What are the mechanisms by which gut mic |
| Gut Barrier Permeability-α-Synuclein Axis Modulation | 0.487 | neurodegeneration | What are the mechanisms by which gut mic |
| Gut-Brain Axis M-Cell Modulation | 0.427 | - | Neuroinflammation and microglial priming |
| Gut-Brain Axis Microbiome Modulation | 0.421 | Alzheimer's disease | Neuroinflammation and microglial priming |
| Correcting Gut Microbial Dopamine Imbalance to Support Syste | 0.412 | neurodegeneration | What are the mechanisms by which gut mic |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675
neurodegeneration | 2026-04-12 | 2 hypotheses Top: 0.537
pharmacokinetics | 2026-04-11 | 0 hypotheses
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Betulinic Acid Reduces Intestinal Inflammation and Enhances Intestinal Tight Jun [PMID:40647158] | ["Zheng X", "Cao Z", "Wang M", "Yuan R", | Nutrients | 2025 | 1 |
| Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology [PMID:38750854] | He C, Jiang J, Liu J, Zhou L, Ge Y, Yang | International journal of biolo | 2024 | 1 |
| USP22 suppresses the NLRP3 inflammasome by degrading NLRP3 via ATG5-dependent au [PMID:35900990] | ["Di Q", "Zhao X", "Tang H", "Li X", "Xi | Autophagy | 2023 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Exploring the gut-kidney axis: Berberine's role in alleviating chronic kidney di [PMID:41344525] | Lu Z, Li Z, Gu S, Cai Y, Wu Y et al. | J Ethnopharmacol | 2026 | 0 |
| Rebalancing the inflammatory niche in allergic rhinitis ". [PMID:41360358] | Wang N, Tang Y | Clin Chim Acta | 2026 | 0 |
| Differentiating Damp-Heat and Cold-Damp Diarrhea in Rat Models via Gut Microbiot [PMID:41566926] | Zhang H, Song X, Mi W, Ji P, Wei Y et al | Microbiologyopen | 2026 | 0 |
| Astragaloside IV Exhibited Antidiabetic Effects by Improving Glucose Metabolism, [PMID:41947478] | Yang X, Zhu C, Liu B, Yang P, Cao Z et a | Phytother Res | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Claudins proteins in brain tumors: expression patterns and therapeutic target. [PMID:41399659] | ["Romanowicz A", "\u0141ukaszewicz-Zaj\u | Biochemia medica | 2026 | 0 |
| Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] | Teng T, Yang S, Li J, Wang H, Wu F, He Y | Neurobiology of disease | 2026 | 0 |
| Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] | Saihati HAA, Ahmed BY, Mosaad RM, El-Gar | Molecular nutrition & food res | 2026 | 0 |
| Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] | Gholizadeh F, Hajiaghayi M, Rahbari N, C | Eur J Immunol | 2026 | 0 |
| Alpha 7 nicotinic acetylcholine receptor contributes to long-term cognitive reco [PMID:41270982] | Nguyen DT, Mendoza K, Hall C, Tan C, Cha | Experimental neurology | 2026 | 0 |
| Putative α7-selective ligands interact with α9-containing nicotinic acetylcholin [PMID:41890755] | Mobasher M, Hone AJ, Pilzecker M, Bozic | Frontiers in immunology | 2026 | 0 |
| Short-term exposure to a high-fat diet leads to neuroinflammation and impairs me [PMID:41565126] | Costa SO, Silva IM, Chaves WF, Esteves A | The Journal of nutritional bio | 2026 | 0 |
| Acetylcholine enhances HIF-1α signaling in pancreatic cancer cells under hypoxia [PMID:41608625] | Cho Y, Kim HG, Kang JH, Oh ET, Park HJ | International journal of biolo | 2026 | 0 |
| Striatal Dysregulation of Angpt2 and Circadian Gene Expression in a Rotenone Rat [PMID:41925987] | Al Saeedy DY, Hawkins E, Dozmorov MG, Tr | J Mol Neurosci | 2026 | 0 |