Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HCN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | HCN3 |
| Full Name | HCN3 |
| Chromosome | 1p22.2 |
| Protein Type | Gene |
| Function | encodes a voltage-gated ion channel subunit that contributes to hyperpolarization-activated inward current (Ih). |
| NCBI Gene ID | Search NCBI |
| GeneCards | HCN3 |
| Human Protein Atlas | HCN3 |
| Associated Diseases | neurodegeneration |
| Interactions | AND |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["HCN3"]
N1["GABA"]
N0 -->|"expressed in"| N1
N2["AND"]
N2 -->|"activates"| N0
N3["HCN1"]
N3 -->|"expressed in"| N0
N4["Ventral Tegmental Area"]
N0 -->|"expressed in"| N4
N5["Neuron"]
N0 -->|"expressed in"| N5
N0 -->|"expressed in"| N3
N6["NEURONS"]
N0 -->|"expressed in"| N6
N7["DOPAMINE"]
N0 -->|"expressed in"| N7
N8["neurodegeneration"]
N0 -->|"implicated in"| N8
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N2 gene
class N3 geneHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||