gene

HCN3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCN3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections
0Hypotheses
0Analyses
6Outgoing
4Incoming
0Experiments

Summary

Page for HCN3

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🧬 Gene Info
Gene SymbolHCN3
Full NameHCN3
Chromosome1p22.2
Protein TypeGene
Functionencodes a voltage-gated ion channel subunit that contributes to hyperpolarization-activated inward current (Ih).
NCBI Gene IDSearch NCBI
GeneCardsHCN3
Human Protein AtlasHCN3
Associated Diseasesneurodegeneration
InteractionsAND
KG Connections10 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

HCN3

gene · 850 words

hcn1-protein

protein · 2123 words

HCN4 — Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 4

gene · 1419 words

HCN4 Protein — HCN Channel 4

protein · 1232 words

HCN and Kv Channel Modulators in Neurodegenerative Disease

therapeutic · 1219 words

KCNK7 Gene

gene · 904 words

Pathway Diagram

flowchart TD
    N0["HCN3"]
    N1["GABA"]
    N0 -->|"expressed in"| N1
    N2["AND"]
    N2 -->|"activates"| N0
    N3["HCN1"]
    N3 -->|"expressed in"| N0
    N4["Ventral Tegmental Area"]
    N0 -->|"expressed in"| N4
    N5["Neuron"]
    N0 -->|"expressed in"| N5
    N0 -->|"expressed in"| N3
    N6["NEURONS"]
    N0 -->|"expressed in"| N6
    N7["DOPAMINE"]
    N0 -->|"expressed in"| N7
    N8["neurodegeneration"]
    N0 -->|"implicated in"| N8

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene

Outgoing (6)

TargetRelationTypeStr
GABAexpressed_ingene0.60
Ventral Tegmental Areaexpressed_inbrain_region0.55
Neuronexpressed_incell_type0.55
HCN1expressed_ingene0.50
NEURONSexpressed_inconcept0.50

Incoming (4)

SourceRelationTypeStr
HCN1expressed_ingene0.60
ANDactivatesgene0.60
HCN1co_mentionedgene0.40
GABAco_mentionedgene0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found