gene

EPILEPSY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPILEPSY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2744Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

EPILEPSY is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with ALS, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS. Connected to 508 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	EPILEPSY
Full Name	Hippocampal CA3 Pyramidal Neurons in Epilepsy
Aliases	Seizure disorder, Epileptic syndrome
Protein Type	Cell Type
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer Disease, Alzheimer'S Disease
Interactions	ALZHEIMER'S DISEASE, AMYLOID, ALZHEIMER, NEUROINFLAMMATION, MICROGLIA, ERBB4
KG Connections	1552 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Hippocampal CA3 Pyramidal Neurons in Epilepsy

cell · 3155 words

→

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

flowchart TD
    EPILEPSY(["EPILEPSY"])
    Epilepsy["Epilepsy"]
    Als["Als"]
    Inflammation["Inflammation"]
    Neurodegeneration["Neurodegeneration"]
    ALZHEIMER_S_DISEASE(["ALZHEIMER'S DISEASE"])
    ALZHEIMER(["ALZHEIMER"])
    Mtor["Mtor"]
    MTOR(["MTOR"])
    Alzheimer["Alzheimer"]
    Parkinson["Parkinson"]
    Neuroinflammation["Neuroinflammation"]

    EPILEPSY -->|"associated with"| Epilepsy
    EPILEPSY -->|"therapeutic target"| Als
    EPILEPSY -->|"therapeutic target"| Epilepsy
    EPILEPSY -->|"activates"| Inflammation
    EPILEPSY -->|"activates"| Als
    EPILEPSY -->|"activates"| Neurodegeneration
    EPILEPSY -->|"associated with"| ALZHEIMER_S_DISEASE
    EPILEPSY -->|"associated with"| ALZHEIMER
    EPILEPSY -->|"therapeutic target"| Mtor
    EPILEPSY -->|"therapeutic target"| MTOR
    ALZHEIMER_S_DISEASE -->|"associated with"| EPILEPSY
    EPILEPSY -->|"associated with"| Alzheimer
    EPILEPSY -->|"causes"| Epilepsy
    EPILEPSY -->|"associated with"| Parkinson
    EPILEPSY -->|"activates"| Neuroinflammation

    style EPILEPSY fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (1321)

Target	Relation	Type	Str
Epilepsy	associated_with	disease	1.00
Als	therapeutic_target	disease	1.00
Epilepsy	therapeutic_target	disease	1.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Neurodegeneration	activates	disease	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ALZHEIMER	associated_with	gene	1.00
Mtor	therapeutic_target	pathway	1.00
MTOR	therapeutic_target	gene	1.00
Alzheimer	associated_with	disease	0.95
Epilepsy	causes	disease	0.95
Parkinson	associated_with	disease	0.95
Neuroinflammation	activates	disease	0.95
Alzheimer	therapeutic_target	disease	0.95
PARKINSON	associated_with	gene	0.90
ASTROCYTE	activates	gene	0.90
ALZHEIMER	therapeutic_target	gene	0.90
Epilepsy	contributes_to	disease	0.85
Epilepsy	regulates	disease	0.85
Inflammation	therapeutic_target	disease	0.85
Neuroinflammation	therapeutic_target	disease	0.85
Parkinson	therapeutic_target	disease	0.85
Als	associated_with	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
neuron excitement	causes	biological_process	0.80
Autophagy	activates	pathway	0.80
PARKINSON'S DISEASE	associated_with	gene	0.80
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.80
Apoptosis	activates	pathway	0.80
Blood-Brain Barrier	therapeutic_target	pathway	0.80
ASTROCYTES	activates	gene	0.80
Oxidative Stress	therapeutic_target	pathway	0.80
Depression	associated_with	disease	0.75
Parkinson	regulates	disease	0.75
Neuroinflammation	inhibits	disease	0.75
Alzheimer	contributes_to	disease	0.75
Multiple Sclerosis	contributes_to	disease	0.75
Parkinson	contributes_to	disease	0.75
Inflammation	regulates	disease	0.75
Ischemia	associated_with	disease	0.75
Epilepsy	activates	disease	0.75
Alzheimer	activates	disease	0.75
Stroke	activates	disease	0.75
Als	regulates	disease	0.75
Aging	activates	disease	0.75
Insulin Resistance	activates	disease	0.75
Depression	therapeutic_target	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Inflammation	associated_with	disease	0.75

Incoming (1423)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	0.98
CORTEX	interacts_with	brain_region	0.95
ASTROCYTES	associated_with	cell_type	0.90
RELN	implicated_in	entity	0.85
PROPOFOL	treats	entity	0.85
HCN1	implicated_in	entity	0.85
HCN CHANNEL BLOCKERS	therapeutic_target	entity	0.85
HCN1 DOWNREGULATION	contributes_to	entity	0.85
HCN2	implicated_in	entity	0.85
HCN4	implicated_in	entity	0.85
ALS	associated_with	disease	0.82
MTOR	associated_with	gene	0.82
ALZHEIMER'S DISEASE	regulates	gene	0.82
ALZHEIMER'S DISEASE	implicated_in	disease	0.80
GABRA1	implicated_in	gene	0.80
GABRA1	causes	gene	0.80
GABRG2	causes	gene	0.80
APOPTOSIS	activates	gene	0.80
MTOR	inhibits	gene	0.74
JUN	associated_with	gene	0.74
MICROGLIA	associated_with	cell_type	0.74
NEURODEVELOPMENTAL_DISORDER	associated_with	disease	0.72
PARKINSON'S DISEASE	contributes_to	gene	0.70
OVERVIEW	regulates	gene	0.70
NEURODEGENERATIVE DISEASES	activates	gene	0.70
GENES	activates	gene	0.70
GENES	therapeutic_target	gene	0.70
NEUROTOXICITY	activates	gene	0.70
OXIDATIVE STRESS	therapeutic_target	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
MIRNAS	therapeutic_target	gene	0.70
CYP46A1	implicated_in	gene	0.70
AMYLOID	associated_with	gene	0.66
ASTROCYTES	activates	gene	0.66
MTOR	activates	gene	0.66
MICROGLIA	interacts_with	cell_type	0.66
APOPTOSIS	associated_with	gene	0.65
CANCER	interacts_with	disease	0.65
CORTEX	expressed_in	brain_region	0.65
CANCER	treats	disease	0.65
DEPRESSION	targets	disease	0.65
NEURONS	targets	cell_type	0.65
GLUT4	transports	gene	0.65
NGF	interacts_with	gene	0.65
NECROPTOSIS	protects_against	phenotype	0.65
GLUTAMATE	causes	phenotype	0.65
NEUROGENESIS	activates	phenotype	0.65
MICROGLIA	exacerbates	cell_type	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do P/Q channel deficits paradoxically increase thalamic excitability despite

synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EPILEPSY

Understanding Entity Pages

Summary

Wiki Pages (21)

Hippocampal CA3 Pyramidal Neurons in Epilepsy

cbs-psp-daily-action-plan

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Device Therapies Comparison for CBS/PSP

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

GRIA3 Gene

Astrocyte Reactivity Mechanism

CNTN5 — Contactin 5

Autophagy Mechanisms

ncam2

gabaergic-dysfunction

CNTN4 — Contactin 4

blood-brain-barrier

nf1-protein

Niemann-Pick Disease Type C (NPC)

Traumatic Brain Injury and Neurodegeneration Pathway

Excitotoxicity in Neurodegeneration

Neuronal Ceroid Lipofuscinosis (NCL)

Neuroprotection Strategies in Neurodegeneration

MACF1 — Microtubule-actin crosslinking factor 1