protein

HES1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HES1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	HES1PROTEIN
Chromosome	3q29.
Protein Type	Transcription Factor
Function	is a protein encoded by the HES1 gene that hes1 is a key notch signaling effector:.
Molecular Weight	30 kDa
Amino Acids	280 aa
GeneCards	HES1PROTEIN
Human Protein Atlas	HES1PROTEIN
Notch Signaling Pathway	Primary activation pathway for HES1
RBPJ	Co-factor required for HES1 transcriptional activation
HES3, HES5, HES7	Related bHLH repressor proteins with partially overlapping functions
Neural Progenitor Cells	Primary cells regulated by HES1
Associated Diseases	neurodegeneration
Interactions	ALS, ALZHEIMER, ALZHEIMER DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND
KG Connections	75 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HES1 (Hairy and Enhancer of Split 1) Protein

protein · 660 words

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Pathway Diagram

graph TD
    HES1PROTEIN["HES1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HES1PROTEIN -->|"implicated_in"| neurodegeneration
    style HES1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HES1PROTEIN in their description or question text

No additional research found