protein 660 words KG: HES1PROTEIN 2026-03-20
kind:proteinsection:proteinsstate:published
Contents

HES1 (Hairy and Enhancer of Split 1) Protein

🔬 Protein Info
Gene SymbolHES1PROTEIN
Chromosome3q29.
Protein TypeTranscription Factor
Functionis a protein encoded by the HES1 gene that hes1 is a key notch signaling effector:.
Molecular Weight30 kDa
Amino Acids280 aa
GeneCardsHES1PROTEIN
Human Protein AtlasHES1PROTEIN
Notch Signaling PathwayPrimary activation pathway for HES1
RBPJCo-factor required for HES1 transcriptional activation
HES3, HES5, HES7Related bHLH repressor proteins with partially overlapping functions
Neural Progenitor CellsPrimary cells regulated by HES1
Associated Diseasesneurodegeneration
InteractionsNESTIN, GFAP, SOD1, DLL4, OLIG2, PSEN1
KG Connections75 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (11)

Purinergic Signaling Polarization Control
Score: 0.55
Mechanosensitive Ion Channel Reprogramming
Score: 0.51
Lipid Droplet Dynamics as Phenotype Switches
Score: 0.46
Circadian-Synchronized Proteostasis Enhancement
Score: 0.58
Circadian Clock-Autophagy Synchronization
Score: 0.55

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
ALS Therapeutic Landscape — Programs by Phase and Modal
disease · Pages share 3 hypotheses
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses
WNK1-Bilirubin Signaling in Neuroinflammation and Neuro
mechanism · Pages share 3 hypotheses
vip-vasoactive-intestinal-peptide-signaling-neurodegene
mechanism · Pages share 3 hypotheses