gene

AMYOTROPHIC LATERAL SCLEROSIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYOTROPHIC LATERAL SCLEROSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5729Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

AMYOTROPHIC LATERAL SCLEROSIS is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 1540 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	AMYOTROPHIC LATERAL SCLEROSIS
Associated Diseases	ALS, ATAXIA, Aging, Alzheimer, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	RAPAMYCIN, CRYPTOXANTHIN
Interactions	NEURODEGENERATIVE DISORDERS, SQSTM1, AUTOPHAGY, APOPTOSIS, NEUROTOXICITY, NEUROINFLAMMATION
KG Connections	2765 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"associated"| Als["Als"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"associated"| Ms["Ms"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"associated"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"regulates"| Alzheimer["Alzheimer"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"activates"| Neurodegeneration["Neurodegeneration"]
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"] -->|"contributes to"| Als_1["Als"]
    OPTN["OPTN"] -->|"associated"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    P62["P62"] -->|"associated"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    MICROGLIA["MICROGLIA"] -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    style AMYOTROPHIC_LATERAL_SCLEROSIS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (2447)

Target	Relation	Type	Str
ALS	associated_with	gene	1.00
Als	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	associated_with	disease	1.00
Alzheimer	regulates	disease	1.00
Neurodegeneration	activates	disease	1.00
Amyotrophic Lateral Sclerosis	regulates	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Parkinson	regulates	disease	1.00
Autophagy	therapeutic_target	pathway	1.00
Dementia	associated_with	disease	1.00
Alzheimer	associated_with	disease	1.00
Huntington	associated_with	disease	1.00
Parkinson	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	1.00
Als	biomarker_for	disease	1.00
Amyotrophic Lateral Sclerosis	biomarker_for	disease	1.00
Neurodegeneration	regulates	disease	1.00
Multiple Sclerosis	associated_with	disease	1.00
Inflammation	therapeutic_target	disease	1.00
Neuroinflammation	therapeutic_target	disease	1.00
Amyotrophic Lateral Sclerosis	activates	disease	1.00
Parkinson	activates	disease	1.00
Inflammation	activates	disease	1.00
Aging	associated_with	disease	1.00
Als	activates	disease	1.00
Als	regulates	disease	1.00
Stroke	associated_with	disease	1.00
Inflammation	associated_with	disease	1.00
Oxidative Stress	therapeutic_target	pathway	1.00
Als	interacts_with	disease	1.00
Amyotrophic Lateral Sclerosis	inhibits	disease	1.00
Amyotrophic Lateral Sclerosis	expressed_in	disease	1.00
Ataxia	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	interacts_with	disease	1.00
Alzheimer	activates	disease	1.00
Neurodegeneration	associated_with	disease	1.00
NEUROINFLAMMATION	associated_with	gene	1.00
Neuroinflammation	associated_with	disease	1.00
Amyotrophic Lateral Sclerosis	causes	disease	1.00
NEURON	associated_with	gene	1.00
MICROGLIA	activates	gene	1.00
DEMENTIA	causes	gene	1.00
Huntington	causes	disease	1.00
Dementia	causes	disease	1.00
Inflammation	regulates	disease	1.00
Neurodegeneration	causes	disease	1.00
OPTN	associated_with	gene	1.00
DEMENTIA	associated_with	gene	1.00
Als	causes	disease	1.00

Incoming (3282)

Source	Relation	Type	Str
OPTN	associated_with	gene	1.00
NEURODEGENERATION	activates	gene	1.00
NEURODEGENERATIVE DISEASES	associated_with	gene	1.00
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
HUNTINGTON'S DISEASE	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
PARKINSON'S DISEASE	activates	gene	1.00
INFLAMMATION	activates	gene	1.00
ALS	regulates	gene	1.00
ASTROCYTES	activates	gene	1.00
ALS	associated_with	gene	1.00
ALS	therapeutic_target	gene	1.00
NEURODEGENERATIVE DISEASES	activates	gene	1.00
MOTOR NEURONS	associated_with	gene	1.00
C9ORF72	associated_with	gene	1.00
ALZHEIMER'S DISEASE	activates	gene	1.00
ALS	interacts_with	gene	1.00
ALS	activates	gene	1.00
CYTOKINES	activates	gene	1.00
PARKINSON	associated_with	gene	1.00
HUNTINGTON	associated_with	gene	1.00
GENES	activates	gene	1.00
ALS	causes	gene	1.00
ALZHEIMER	associated_with	gene	1.00
C9ORF72	causes	gene	1.00
SOD1	causes	gene	1.00
NEURODEGENERATION	causes	gene	1.00
GENES	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
ALZHEIMER	regulates	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
PARKINSON	activates	gene	1.00
ALZHEIMER	activates	gene	1.00
NEURODEGENERATIVE DISEASES	implicated_in	gene	1.00
NEURODEGENERATION	implicated_in	gene	1.00
DNA	therapeutic_target	gene	1.00
ALS	biomarker_for	gene	1.00
ALZHEIMER'S DISEASE	regulates	gene	1.00
NEURODEGENERATION	regulates	gene	1.00
MOTOR NEURONS	activates	gene	1.00
INFLAMMATION	associated_with	gene	1.00
DNA	interacts_with	gene	1.00
MOTOR NEURONS	causes	gene	1.00
ALS	inhibits	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
NEURODEGENERATIVE DISORDERS	associated_with	gene	1.00
PARKINSON	regulates	gene	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do the seven novel ALS genes function in animal models to cause neurodegener

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.520

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMYOTROPHIC LATERAL SCLEROSIS

Understanding Entity Pages

Summary

Wiki Pages (20)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

primary-progressive-aphasia

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

nhp-validation-animal-model

nimodipine-als

Therapeutics

NPM1 Gene

Neurons — Cell Type Hierarchy

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Alzheimer's Disease

Frontotemporal Dementia (FTD)