gene

HSPA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

4Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for HSPA2 Gene

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	HSPA2
Chromosome	14q23.3.
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	70.0 kDa
Amino Acids	642 aa
Ensembl ID	ENSG00000113013
GeneCards	HSPA2
Human Protein Atlas	HSPA2
Testis	Very high expression in spermatocytes and spermatids
Brain	Low expression in certain neuronal populations
Epididymis	Moderate expression
Regulation	Testis-specific transcription factors (CREM) regulate expression
Cellular localization	Cytosolic with nuclear translocation during chromatin remodeling
Associated Diseases	neurodegeneration
Interactions	PROTEIN MISFOLDING
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HSPA2 Gene

gene · 646 words

→

HSPA2 Protein

protein · 784 words

→

Pathway Diagram

graph TD
    HSPA2["HSPA2"]
    Alzheimer{"Alzheimer"}
    HSPA2 -->|"biomarker for"| Alzheimer
    HSP70["HSP70"]
    HSPA2 -->|"biomarker for"| HSP70
    HSPA1A["HSPA1A"]
    HSPA2 -->|"biomarker for"| HSPA1A
    HSPA8["HSPA8"]
    HSPA2 -->|"biomarker for"| HSPA8
    neurodegeneration["neurodegeneration"]
    HSPA2 -->|"implicated in"| neurodegeneration
    PROTEIN_MISFOLDING["PROTEIN MISFOLDING"]
    PROTEIN_MISFOLDING -->|"inhibits"| HSPA2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"biomarker for"| HSPA2
    style HSPA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

Target	Relation	Type	Str
Alzheimer	biomarker_for	disease	0.65
HSP70	biomarker_for	gene	0.60
HSPA1A	biomarker_for	gene	0.60
HSPA8	biomarker_for	gene	0.60

Incoming (2)

Source	Relation	Type	Str
PROTEIN MISFOLDING	inhibits	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSPA2 in their description or question text

No additional research found