protein

HSP70

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1200Connections

16Hypotheses

19Analyses

50Outgoing

50Incoming

1Experiments

20Debates

Summary

HSP70 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Als. Connected to 481 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	HSPA1A
Full Name	Heat Shock Protein Family A (Hsp70) Member 1A/1B
Aliases	HSP70
Chromosome	6p21.33 (HSPA1A), 6p21.33 (HSPA1B)
Protein Family	Heat shock protein 70 family (HSP70 superfamily)
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Cytoplasm, nucleus (stress-induced)
Molecular Weight	70 kDa
Amino Acids	640 aa
Pathways	Akt, Apoptosis, Chaperone, Complement, Epithelial-Mesenchymal Transition
UniProt ID	P0DMV8
OMIM	140100
GeneCards	HSPA1A
Human Protein Atlas	HSPA1A
Associated Diseases	Als, Alzheimer, alzheimer_disease, alzheimers, cancer
Known Drugs/Compounds	5S rRNA, 5S Rrna, aducanumab, Arimoclomol, Geranylgeranylacetone, lecanemab
Interactions	Actin, ADAM10, AIMP2-DX2, AKT, AKT1, AKT1S1
SciDEX Hypotheses	Chaperone Hijacking Interference Therapy
KG Connections	1174 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HSP70 — AlphaFold P0DMV8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

HSP70 (Heat Shock Protein 70 / HSPA1A)

protein · 1532 words

→

Validated Hypothesis: Exposed amyloidogenic segments (β-sheet propensity residues) serve as HSP70 recognition codes

hypothesis · 2687 words

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Validated Hypothesis: J-protein substrate specificity codes enable HSP70 discrimination of β-sheet versus α-helical misfolded conformers

hypothesis · 1115 words

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Pathway Diagram

flowchart TD
    HSP70(["HSP70"])
    Nf__b["Nf-Kappab"]
    NF__B(["NF-KappaB"])
    Inflammation["Inflammation"]
    Als["Als"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Cancer["Cancer"]
    Apoptosis["Apoptosis"]
    poly_GA_aggregates("poly-GA aggregates")
    Oxidative_Stress["Oxidative Stress"]
    AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
    UBQLN2(["UBQLN2"])
    TIA1(["TIA1"])
    PI3K(["PI3K"])

    HSP70 -->|"regulates"| Nf__b
    NF__B -->|"regulates"| HSP70
    HSP70 -->|"activates"| Inflammation
    HSP70 -->|"activates"| Als
    HSP70 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    HSP70 -->|"regulates"| Cancer
    HSP70 -->|"regulates"| Apoptosis
    HSP70 -->|"activates"| poly_GA_aggregates
    HSP70 -->|"therapeutic target"| Apoptosis
    HSP70 -->|"therapeutic target"| Oxidative_Stress
    HSP70 -->|"activates"| Apoptosis
    HSP70 -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS
    UBQLN2 -->|"interacts with"| HSP70
    TIA1 -.->|"inhibits"| HSP70
    PI3K -->|"regulates"| HSP70

    style HSP70 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (748)

Target	Relation	Type	Str
HSP70	encodes	protein	0.00
5S Rrna	binds	compound	0.95
Trna	binds	compound	0.95
Non-Coding Rna	interacts_with	compound	0.95
cognitive impairment	associated_with	unknown	0.95
Cellular Homeostasis	associated_with	process	0.95
protein_aggregation	inhibits	mechanism	0.95
sleep deprivation	associated_with	mechanism	0.95
anxiety-like behavior	associated_with	unknown	0.95
Non-coding RNA	binds	process	0.95
alzheimer_disease	modulates	disease	0.95
5S rRNA	binds	compound	0.92
tRNA	binds	compound	0.92
Cancer	associated_with	disease	0.90
tau aggregates	disaggregates	mechanism	0.90
RNA Polymerase III	regulates	enzyme	0.90
Non-Coding Rna Biogenesis	involved_in	process	0.90
ischemic_injury	associated_with	unknown	0.90
proteotoxic stress	biomarker_for	unknown	0.90
Trna Gene Transcription	modulates	process	0.90
Rna Polymerase Iii	regulates	protein	0.90
cerebral ischemia-reperfusion injury	protects_against	unknown	0.90
Protein Folding	involved_in	process	0.90
neuronal_survival	associated_with	unknown	0.90
Neurodegeneration	associated_with	disease	0.90
AIMP2-DX2	regulates	protein	0.90
tRNA Gene Transcription	upregulates	process	0.88
necrosis	inhibits	unknown	0.85
Huntington's disease	suppresses	unknown	0.85
SIAH1	inhibits	protein	0.85
Sleep	associated_with	process	0.85
Sleep Disorders	targets	disease	0.85
AIMP2-DX2	co_expressed_with	protein	0.85
oxidative_stress	biomarker_for	phenotype	0.85
alpha_synuclein_aggregation	degrades	mechanism	0.85
mitochondrial_dysfunction	modulates	mechanism	0.85
Protein Homeostasis	involved_in	process	0.85
TDP-43 aggregation	inhibits	mechanism	0.85
Cell Transformation	modulates	process	0.80
Tumor Progression	associated_with	process	0.80
GCase	interacts_with	protein	0.80
TDP-43_aggregation	prevents	phenotype	0.80
Apoptosis	regulates	process	0.80
alpha_synuclein_aggregation	inhibits	mechanism	0.80
small molecule chaperones	associated_with	drug	0.80
cell damage	associated_with	unknown	0.80
CMA	associated_with	process	0.80
UBQLN2	interacts_with	gene	0.80
protein_folding_pathway	participates_in	pathway	0.80
Nf-Κb	regulates	pathway	0.80

Incoming (452)

Source	Relation	Type	Str
HSP70	encodes	gene	0.00
stress granule formation	associated_with	mechanism	0.95
DNAJB6	binds	protein	0.95
DNAJB6	interacts_with	protein	0.95
AIMP2-DX2	interacts_with	protein	0.95
TSG-6	upregulates	unknown	0.95
DNAJB6	activates	protein	0.90
DNAJB1	enhances	protein	0.90
GCase	interacts_with	protein	0.85
Copper	upregulates	compound	0.85
small molecule chaperones	activates	drug	0.85
HSP40	activates	gene	0.85
small_molecule_chaperones	activates	unknown	0.80
APE2	binds	gene	0.80
BHB	upregulates	compound	0.80
Geranylgeranylacetone	activates	drug	0.80
Arimoclomol	activates	drug	0.80
Allosteric Mechanisms	regulates	mechanism	0.80
HSPA1A	encodes	gene	0.80
NF-ΚB	regulates	gene	0.80
small molecule chaperones	associated_with	drug	0.75
DNAJB1	activates	gene	0.75
HIF	regulates	gene	0.70
CANCER	regulates	gene	0.70
co-chaperones	regulates	protein	0.70
TIA1	inhibits	gene	0.70
UBQLN2	interacts_with	gene	0.70
PI3K	regulates	gene	0.70
APOPTOSIS	regulates	gene	0.70
small_molecule_chaperones	associated_with	unknown	0.70
GDNF	protects_against	gene	0.65
DNAJA1	activates	gene	0.65
APOE4	regulates	gene	0.65
APOE4	activates	gene	0.65
HSP40	associated_with	gene	0.65
HSP40	interacts_with	gene	0.65
HUNTINGTON'S DISEASE	inhibits	gene	0.60
HER2	inhibits	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
NRBF2	interacts_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
AMYLOID	associated_with	gene	0.60
CANCER	stabilizes	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MITOPHAGY	interacts_with	gene	0.60
SOD2	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (16)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Exposed amyloidogenic segments (β-sheet propensity residues)	0.840	protein-biochemistry	Do chaperones selectively recognize path
J-protein substrate specificity codes enable HSP70 discrimin	0.840	protein-biochemistry	Do chaperones selectively recognize path
H4: Age-Related Hsp70 Chaperone Decline Blocks Granule Rever	0.577	neurodegeneration	How do pathological stress granules tran
Hsp70-based therapy to prevent lysosomal membrane permeabili	0.570	neuroscience	Lysosomal dysfunction and cathepsin leak
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.544	neurodegeneration	Protein aggregation cross-seeding across

BAG3-Mediated Hsp70 Substrate Redistribution	0.540	neurodegeneration	How does controlled lysosomal membrane p
APOE4 Structural Remodeling via HSP70 Chaperone Enhancement	0.486	molecular-biology	Is APOE4's reduced lipid binding pathoge
Isoform-Selective Hsp70 Targeting Overcomes Stoichiometric I	0.481	protein-folding	Can chaperone enhancement approaches ove
Tau Conformation-Selective HSP70 Inhibition	0.455	drug-discovery	What are the minimal structural requirem
Temporal Gating Through HSP70 ATPase Cycle Manipulation	0.455	drug-discovery	What are the minimal structural requirem
Hsp70 cochaperone BAG3-mediated Autophagy Activation for Syn	0.447	proteomics	Quantitative proteomics of the aging syn
HSP70/HSP40 Chaperone Complex Secretion	0.380	neurodegeneration	Which specific factors in conditioned me
Amyloidogenic segments undergo conformational templating by	0.380	protein-biochemistry	Do chaperones selectively recognize path
HSP70 recognition of exposed β-sheet segments triggers CHIP-	0.380	protein-biochemistry	Do chaperones selectively recognize path
Exposed amyloidogenic segments trigger CHIP-mediated oligome	0.380	protein-biochemistry	Do chaperones selectively recognize path
Chaperone Hijacking Interference Therapy	0.000	-	What determines the selectivity and effi

Mentioning Analyses (19)

Scientific analyses that reference this entity

What is the molecular mechanism by which rutin inhibits tau aggregation and olig

neurodegeneration | 2026-04-25 | 3 hypotheses Top: 0.627

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

proteomics | 2026-04-16 | 19 hypotheses Top: 0.591

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.521

Do chaperones selectively recognize pathological vs physiological protein confor

protein biochemistry | 2026-04-10 | 17 hypotheses Top: 0.840

What determines the selectivity and efficiency of intercellular transmission pat

neurodegeneration | 2026-04-08 | 4 hypotheses Top: 0.380

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Nation-wide NGS-based genetic screening of LGMD patients in US	exploratory	Limb-girdle muscular dystrophy	0.950	0.00	Human patients	proposed	N/A

Related Papers (16)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
DNAJB6: A guardian against neurodegeneration. [PMID:40536953]	Hentze J, Gelman A, Brudek T, Hansen C	Neural regeneration research	2026
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non- [PMID:41271702]	Resnick SJ, Qamar S, Krishna P, Korobeyn	Nature communications	2025
Extracellular chaperone networks and the export of J-domain proteins. [PMID:36581212]	Braun JEA	The Journal of biological chem	2023
DNAJB6 mutants display toxic gain of function through unregulated interaction wi [PMID:37923706]	Abayev-Avraham M, Salzberg Y, Gliksberg	Nature communications	2023
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022
The chaperone DNAJB6 surveils FG-nucleoporins and is required for interphase nuc [PMID:36302971]	Kuiper EFE, Gallardo P, Bergsma T, Mari	Nature cell biology	2022
A 20-year Clinical and Genetic Neuromuscular Cohort Analysis in Lebanon: An Inte [PMID:34602496]	Megarbane A, Bizzari S, Deepthi A, Sabba	Journal of neuromuscular disea	2022
DNAJB6 suppresses alpha-synuclein induced pathology in an animal model of Parkin [PMID:34390836]	["Arkan S", "Ljungberg M", "Kirik D", "H	Neurobiology of disease	2021
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021
Panorama of the distal myopathies. [PMID:33458580]	Savarese M, Sarparanta J, Vihola A, Jons	Acta myologica : myopathies an	2020
Functional characterization of 84 PALB2 variants of uncertain significance. [PMID:31636395]	Wiltshire T, Ducy M, Foo TK, Hu C, Lee K	Genetics in medicine : officia	2020
DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis. [PMID:32268123]	["Thiruvalluvan A", "de Mattos E", "Brun	Molecular cell	2020
Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment [PMID:30737131]	Merlini M, Rafalski VA, Rios Coronado PE	Neuron	2019
Genetic landscape and novel disease mechanisms from a large LGMD cohort of 4656 [PMID:30564623]	Nallamilli BRR, Chakravorty S, Kesari A,	Annals of clinical and transla	2018
Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer. [PMID:27276715]	Meng E, Shevde LA, Samant RS	Oncotarget	2016

Debates (20)

Multi-agent debates referencing this entity

What is the molecular mechanism by which rutin inhibits tau aggregation and olig

closed · Rounds: 4 · Score: 0.66 · 2026-04-25

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

closed · Rounds: 4 · Score: 0.73 · 2026-04-22

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

The debate revealed fundamental uncertainty about whether HSP70/HSP90 systems ca

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

How does synaptic protein turnover change with age and neurodegeneration, and wh

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Investigate prion-like spreading of tau pathology through connected brain region

closed · Rounds: 4 · Score: 0.90 · 2026-04-12

TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small

closed · Rounds: 6 · Score: 0.84 · 2026-04-12

TDP-43 phase separation therapeutics for ALS-FTD

closed · Rounds: 4 · Score: 0.95 · 2026-04-11

The abstract identifies tissue-specific networks that may underlie Mendelian dis

closed · Rounds: 6 · Score: 0.95 · 2026-04-10

Related Research

Hypotheses and analyses mentioning HSP70 in their description or question text

HSP70

Understanding Entity Pages

Summary

Wiki Pages (10)

HSP70 (Heat Shock Protein 70 / HSPA1A)

Validated Hypothesis: Exposed amyloidogenic segments (β-sheet propensity residues) serve as HSP70 recognition codes

Alzheimer's Disease HSP70/HSP90 Chaperone and Protein Folding Therapy Companies

HSP70/HSP90 Modulators

HSP70 Protein

Validated Hypothesis: J-protein substrate specificity codes enable HSP70 discrimination of β-sheet versus α-helical misfolded conformers

HSP70 Inducer Therapies for Neurodegeneration

HSP70 Inducer Therapies for Neurodegeneration

HSP70 Gene

HSP70 Inducer Therapies

Pathway Diagram

Outgoing (748)

Incoming (452)

Targeting Hypotheses (16)

Mentioning Analyses (19)

What is the molecular mechanism by which rutin inhibits tau aggregation and olig

Quantitative proteomics of the aging synapse: protein turnover and aggregation i

How do ALS-associated OPTN mutations mechanistically disrupt Rab8a binding and c

Do chaperones selectively recognize pathological vs physiological protein confor

What determines the selectivity and efficiency of intercellular transmission pat

How do host cell factors influence the conformation and propagation properties o

What molecular mechanisms drive tissue-specific phenotypes in Mendelian neurolog

How does controlled lysosomal membrane permeabilization induce autophagy without

Can chaperone enhancement approaches overcome tau seed saturation effects in adv

Tau propagation mechanisms and therapeutic interception points

GBA-Synuclein Loop Therapeutics for PD

Epigenetic clocks and biological aging in neurodegeneration

Digital biomarkers and AI-driven early detection of neurodegeneration

APOE4 structural biology and therapeutic targeting strategies

TDP-43 phase separation therapeutics for ALS-FTD

TDP-43 phase separation therapeutics for ALS-FTD

APOE4 structural biology and therapeutic targeting strategies

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Mechanistic role of APOE in neurodegeneration

Experiments (1)

Related Papers (16)

Debates (20)

What is the molecular mechanism by which rutin inhibits tau aggregation and olig

While DNAJB1 enhancement showed promise, the debate raised concerns about whethe

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

The debate revealed fundamental uncertainty about whether HSP70/HSP90 systems ca

How does synaptic protein turnover change with age and neurodegeneration, and wh

The authors evaluate several ALS-associated mutations in OPTN's leucine-zipper d

Investigate prion-like spreading of tau pathology through connected brain region

TDP-43 undergoes liquid-liquid phase separation that becomes pathological. Small

TDP-43 phase separation therapeutics for ALS-FTD

The abstract identifies tissue-specific networks that may underlie Mendelian dis

Related Research

BAG3-Mediated Hsp70 Substrate Redistribution

APOE4 Structural Remodeling via HSP70 Chaperone Enhancement Strategy

Isoform-Selective Hsp70 Targeting Overcomes Stoichiometric Imbalance in Advanced

Tau Conformation-Selective HSP70 Inhibition

Temporal Gating Through HSP70 ATPase Cycle Manipulation

Hsp70 cochaperone BAG3-mediated Autophagy Activation for Synaptic Protein Qualit

HSP70/HSP40 Chaperone Complex Secretion

Amyloidogenic segments undergo conformational templating by HSP90-HSP70 heteroco

HSP70 recognition of exposed β-sheet segments triggers CHIP-mediated selective d

Exposed amyloidogenic segments trigger CHIP-mediated oligomer-selective ubiquiti

Chaperone Hijacking Interference Therapy