HSP70

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP70: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HSP70 is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Als. Connected to 481 entities in the SciDEX knowledge graph.

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flowchart TD
    HSP70(["HSP70"])
    Nf__b["Nf-Kappab"]
    NF__B(["NF-KappaB"])
    Inflammation["Inflammation"]
    Als["Als"]
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    Cancer["Cancer"]
    Apoptosis["Apoptosis"]
    poly_GA_aggregates("poly-GA aggregates")
    Oxidative_Stress["Oxidative Stress"]
    AMYOTROPHIC_LATERAL_SCLEROSIS(["AMYOTROPHIC LATERAL SCLEROSIS"])
    UBQLN2(["UBQLN2"])
    TIA1(["TIA1"])
    PI3K(["PI3K"])

    HSP70 -->|"regulates"| Nf__b
    NF__B -->|"regulates"| HSP70
    HSP70 -->|"activates"| Inflammation
    HSP70 -->|"activates"| Als
    HSP70 -->|"activates"| Amyotrophic_Lateral_Sclerosis
    HSP70 -->|"regulates"| Cancer
    HSP70 -->|"regulates"| Apoptosis
    HSP70 -->|"activates"| poly_GA_aggregates
    HSP70 -->|"therapeutic target"| Apoptosis
    HSP70 -->|"therapeutic target"| Oxidative_Stress
    HSP70 -->|"activates"| Apoptosis
    HSP70 -->|"activates"| AMYOTROPHIC_LATERAL_SCLEROSIS
    UBQLN2 -->|"interacts with"| HSP70
    TIA1 -.->|"inhibits"| HSP70
    PI3K -->|"regulates"| HSP70

    style HSP70 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0