Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL17B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | IL17B |
| Full Name | Interleukin 17B |
| Chromosome | 9p13.3 |
| Protein Family | IL-17 cytokine family |
| Function | is a cytokine belonging to the IL-17 family that plays important roles in immune regulation, inflammation, and increasingly recognized roles in neuroinflammation and neurodegenerative diseases. |
| Primary Expression | various tissues including brain |
| Molecular Weight | 20 kDa |
| Pathways | NF-κB pathway |
| UniProt ID | Q9UHA0 |
| NCBI Gene ID | 27190 |
| Ensembl ID | ENSG00000188202 |
| OMIM | 604628 |
| GeneCards | IL17B |
| Human Protein Atlas | IL17B |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["IL17B"]
N1["Macrophage Recruitment"]
N0 -->|"promotes"| N1
N2["IL17RB"]
N0 -->|"binds"| N2
N3["Schwann Cell"]
N3 -->|"expressed in"| N0
N4["neurodegeneration"]
N0 -->|"implicated in"| N4
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Macrophage Recruitment | promotes | process | 0.95 |
| IL17RB | binds | receptor | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Schwann Cell | expressed_in | cell_type | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IL17B in their description or question text
No additional research found