Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCHWANN CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SCHWANN CELL |
| Key Genes/Proteins | C9ORF72 |
| Related Diseases | ALS, DIABETES |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
SCHWANN_CELL["SCHWANN CELL"]
SCHWANN_CELL -->|"product_of"| SFRP1["SFRP1"]
SCHWANN_CELL -.biomarker for.-> Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
SCHWANN_CELL -->|"expressed in"| Spinal_Cord["Spinal Cord"]
SFRP1 -->|"expressed in"| SCHWANN_CELL
ALS["ALS"] -->|"regulates"| SCHWANN_CELL
C9ORF72["C9ORF72"] -->|"regulates"| SCHWANN_CELL
AGING["AGING"] -->|"increases"| SCHWANN_CELL
ASTROCYTE["ASTROCYTE"] -->|"increases"| SCHWANN_CELL
MICROGLIA["MICROGLIA"] -->|"increases"| SCHWANN_CELL
INFLAMMATION["INFLAMMATION"] -->|"contributes to"| SCHWANN_CELL
NEURON["NEURON"] -->|"promotes"| SCHWANN_CELL| Target | Relation | Type | Str |
|---|---|---|---|
| SPINAL CORD | co_discussed | brain_region | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS | regulates | disease | 0.65 |
| C9ORF72 | regulates | gene | 0.65 |
| ASTROCYTE | increases | cell_type | 0.65 |
| MICROGLIA | increases | cell_type | 0.65 |
| NEURON | promotes | cell_type | 0.60 |
| ASTROCYTE | co_discussed | cell_type | 0.40 |
| DIABETES | co_discussed | disease | 0.40 |
| MICROGLIA | co_discussed | cell_type | 0.40 |
| OLIGODENDROCYTE | co_discussed | cell_type | 0.40 |
| OLIGODENDROCYTES | co_discussed | cell_type | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| GDNF Gradient Establishment by Schwann Cells Enables Motor R | 0.585 | neurodegeneration | What molecular mechanisms enable functio |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||