gene

IL28B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL28B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

IL28B encodes Interleukin-28B, a type III interferon cytokine involved in antiviral immunity and neuroinflammation in neurodegenerative diseases including Alzheimer's and Parkinson's.

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🧬 Gene Info

Gene Symbol	IL28B
Full Name	Interleukin 28B
Chromosome	19q13.2
Protein Family	Type III Interferons (IFN-λ)
Primary Expression	various brain cell types including neurons, astrocytes, and microglia, where they contribute to neuroinflammation, antiviral defense, and potentially
Molecular Weight	22 kDa
Amino Acids	200 aa
Exons	5
UniProt ID	Q8IZI9
NCBI Gene ID	282617
Ensembl ID	ENSG00000184226
OMIM	607402
GeneCards	IL28B
Human Protein Atlas	IL28B
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL28B — AlphaFold Q8IZI9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL28B (Interleukin 28B)

gene · 3405 words

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Pathway Diagram

graph TD
    IL28B["IL28B"]
    neurodegeneration["neurodegeneration"]
    IL28B -->|"implicated_in"| neurodegeneration
    style IL28B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning IL28B in their description or question text

No additional research found