Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ITE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| AhR | activates | protein | 0.92 |
| Retinal Local Inflammation | downregulates | process | 0.85 |
| Retinal Ischemia/Reperfusion Injury | treats | disease | 0.85 |
| ERK | inhibits | protein | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.567
synaptic biology | 2026-04-14 | 1 hypotheses Top: 0.526
endocrinology | 2026-04-13 | 2 hypotheses Top: 0.572
neurodegeneration | 2026-04-12 | 3 hypotheses Top: 0.700
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Stress granule homeostasis is modulated by TRIM21-mediated ubiquitination of G3B [PMID:36692217] | Yang C, Wang Z, Kang Y, Yi Q, Wang T, Ba | Autophagy | 2023 | 3 |
| G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Gran [PMID:32302571] | Yang P, Mathieu C, Kolaitis RM, Zhang P, | Cell | 2020 | 3 |
| Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] | Yao RQ, Ren C, Xia ZF, Yao YM | Autophagy | 2021 | 2 |
| Role of stress granules in modulating senescence and promoting cancer progressio [PMID:34460104] | Chatterjee D, Chakrabarti O | Int J Cancer | 2022 | 1 |
| Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specifi [PMID:34739333] | Gwon Y, Maxwell BA, Kolaitis RM, Zhang P | Science | 2021 | 1 |
| METTL3/CXCL10 axis contributes to renal fibrosis by promoting the apoptosis of t [PMID:41138934] | Sun Y, Ren Z, Ge J, Zhang W, Shao F et a | Biochim Biophys Acta Mol Basis | 2026 | 0 |
| IL-25-ILC2-IL-13 axis improves traumatic brain injury by mediating CXCL-10-depen [PMID:41527095] | Peng M, Shu D, Chen Z, Yang Z, Zhang M e | J Neuroinflammation | 2026 | 0 |
| Oligodendrocyte transcription factor 2 orchestrates glioblastoma immune evasion [PMID:41591814] | Zhang X, Xue J, Zhao C, Zeng C, Zhong J | J Clin Invest | 2026 | 0 |
| Indole-3-propionic acid inhibits astrocyte inflammation and promotes motor funct [PMID:41663028] | Yu D, Kang J, Jiang W, Zhang C, Zhao X e | Neuropharmacology | 2026 | 0 |
| Cobrotoxin mitigates neuroinflammation and cognitive impairment by suppressing C [PMID:41671614] | Li Z, Tan B, Dong K, Yu X, Zhang SW et a | Biochem Pharmacol | 2026 | 0 |
| Peripheral macrophages and T-cells accumulate in the degenerating optic tract af [PMID:41740873] | Main BS, Villapol S, Buenaventura RG, Ha | Brain Behav Immun | 2026 | 0 |
| Melanoma cell inoculation improves cognitive impairment in the 5xFAD mouse model [PMID:41760781] | Bruna-Jara B, More J, Lobos P, Ponce DP, | Scientific reports | 2026 | 0 |
| Chemokine-defined macrophage niches establish spatial organization of tumor immu [PMID:41872505] | Ghosh S, Li X, Rawat K, Dighal A, Kalino | Nat Immunol | 2026 | 0 |
| Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as [PMID:41941036] | Lai Y, Lin P, Zhang K, Hong W, Zheng M e | Cell Biol Toxicol | 2026 | 0 |
| Primary Infection with Cystoisospora suis Modulates Systemic Immunity and the Gu [PMID:41942044] | Ye X, Huang YJ, Deng XL, He ZY, Tan JJ e | Int J Parasitol | 2026 | 0 |
| Agonists for cytosolic bacterial receptor ALPK1 induce antitumour immunity. [PMID:41372408] | Tian X, Liu J, Li Y, Wang Y, Luo Y, He H | Nature | 2026 | 0 |
| HTLV1-associated myelopathy as a translational model of progressive neurodegener [PMID:41926707] | da Silva MTT, Araujo AQC | Brain : a journal of neurology | 2026 | 0 |
| Unveiling the choroidal immune landscape revealed interferon-gamma and TNF-alpha [PMID:41077603] | Ye L, Zhao T, Tian H, Li R, Li Z et al. | Sci China Life Sci | 2026 | 0 |
| The mechanism of Qing-Fei-Yin decoction against influenza: Synergistical inhibit [PMID:41317805] | Nie W, Wang M, Cheng M, Ren Z, Liu G et | J Ethnopharmacol | 2026 | 0 |
| Elucidating the biological characteristics of overweight populations based on ur [PMID:41529508] | Li Y, Miao Y, Liang H, Zhou K, Li R et a | Spectrochim Acta A Mol Biomol | 2026 | 0 |