Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ERK is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with AD, ALI, ALS. Connected to 1361 entities in the SciDEX knowledge graph.
| Gene Symbol | ERK |
| Pathways | APOPTOSIS |
| GeneCards | ERK |
| Human Protein Atlas | ERK |
| Associated Diseases | AD, ALI, ALS, ALZHEIMER'S DISEASE, AMI, Aging |
| Known Drugs/Compounds | N-ACETYLCYSTEINE, NAC, R-ketamine, Flavonoids, Norepinephrine, plant extracts |
| Interactions | EPHB4, AKT, TP53, EFNB1, SRC, PI3K |
| KG Connections | 2549 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ERK["ERK"] -.->|"inhibits"| TTP["TTP"]
ERK["ERK"] -->|"phosphorylates"| YTHDF2["YTHDF2"]
ERK["ERK"] -->|"activates"| CREB["CREB"]
ERK["ERK"] -->|"interacts"| Carcinoma["Carcinoma"]
ERK["ERK"] -->|"interacts"| Cancer["Cancer"]
ERK["ERK"] -->|"interacts"| Tumor["Tumor"]
SRC["SRC"] -->|"activates"| ERK["ERK"]
FLAVONOIDS["FLAVONOIDS"] -->|"regulates"| ERK["ERK"]
PIEZO1["PIEZO1"] -->|"activates"| ERK["ERK"]
EGFR["EGFR"] -->|"activates"| ERK["ERK"]
style ERK fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Apoptosis | inhibits | pathway | 1.00 |
| AKT | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Mapk | regulates | pathway | 1.00 |
| EGFR | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Als | activates | disease | 1.00 |
| AKT | activates | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Mapk | inhibits | pathway | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| P38 | activates | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| CANCER | activates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| Cancer | regulates | disease | 1.00 |
| JNK | inhibits | gene | 1.00 |
| Pi3K/Akt | inhibits | pathway | 1.00 |
| RAS | activates | gene | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| JNK | activates | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ERK1 | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| BAX | activates | gene | 1.00 |
| MEK | phosphorylates | protein | 0.95 |
| trametinib | inhibits | drug | 0.95 |
| NUPR1 | inhibits | gene | 0.95 |
| MEK | activates | protein | 0.95 |
| SPP1 | activates | protein | 0.92 |
| RB5 | activates | drug | 0.92 |
| SRC | activates | protein | 0.90 |
| AKT | inhibits | gene | 0.90 |
| AMYLOID | associated_with | protein | 0.90 |
| IGF1R | activates | protein | 0.90 |
| NLGN3 | activates | protein | 0.90 |
| mechanotransduction | activates | process | 0.90 |
| MADD | upstream_of | protein | 0.90 |
| FGF2/FGFR1 pathway | upstream_of | pathway | 0.90 |
| CHOLIX | upregulates | drug | 0.90 |
| GCN5 | modulates | protein | 0.90 |
| CREB | activates | gene | 0.90 |
| ITGB1 | activates | protein | 0.88 |
| CD44 | activates | protein | 0.88 |
| TrkB | activates | protein | 0.88 |
| HSPA5 | regulates | entity | 0.85 |
| plant extracts | activates | drug | 0.85 |
| ITE | inhibits | drug | 0.85 |
| NGF | activates | protein | 0.85 |
| GLP-1R | activates | protein | 0.85 |
| ketamine | activates | drug | 0.85 |
| TQYZ | activates | drug | 0.85 |
| HER2 | upstream_of | protein | 0.85 |
| SPRED1 | inhibits | protein | 0.85 |
| AKT | activates | gene | 0.82 |
| APOPTOSIS | inhibits | gene | 0.82 |
| ASTROCYTES | associated_with | cell_type | 0.82 |
| VEGF | activates | protein | 0.82 |
| FLAVONOIDS | regulates | gene | 0.80 |
| NRBP1 | participates_in | gene | 0.80 |
| β2-Adrenergic Receptor | activates | receptor | 0.80 |
| HSPA1A | activates | gene | 0.80 |
| DUSP8 | associated_with | gene | 0.80 |
| Norepinephrine | activates | compound | 0.80 |
| focal adhesion complexes | activates | protein | 0.80 |
| hyperinsulinemia | activates | phenotype | 0.80 |
| phytochemicals | activates | drug | 0.80 |
| AhR | inhibits | protein | 0.80 |
| GPR34 | activates | protein | 0.80 |
| PTEN | inhibits | gene | 0.80 |
| PI3K | associated_with | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||