Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ERK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
ERK is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with AD, ALI, ALS. Connected to 1361 entities in the SciDEX knowledge graph.
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| Gene Symbol | ERK |
| Pathways | APOPTOSIS |
| GeneCards | ERK |
| Human Protein Atlas | ERK |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | Flavonoids, ITE, ketamine, lactate, metformin, NAC |
| Interactions | ABCA1, ABCA7, ABCB1, ACAT1, ACHE, ACSL4 |
| KG Connections | 2628 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ERK["ERK"] -.->|"inhibits"| TTP["TTP"]
ERK["ERK"] -->|"phosphorylates"| YTHDF2["YTHDF2"]
ERK["ERK"] -->|"activates"| CREB["CREB"]
ERK["ERK"] -->|"interacts"| Carcinoma["Carcinoma"]
ERK["ERK"] -->|"interacts"| Cancer["Cancer"]
ERK["ERK"] -->|"interacts"| Tumor["Tumor"]
SRC["SRC"] -->|"activates"| ERK["ERK"]
FLAVONOIDS["FLAVONOIDS"] -->|"regulates"| ERK["ERK"]
PIEZO1["PIEZO1"] -->|"activates"| ERK["ERK"]
EGFR["EGFR"] -->|"activates"| ERK["ERK"]
style ERK fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ERK | encodes | protein | 0.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Pi3K/Akt | inhibits | pathway | 1.00 |
| Cancer | regulates | disease | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| P38 | activates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| AKT | activates | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Mapk | inhibits | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| JNK | inhibits | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Als | regulates | disease | 1.00 |
| Mapk | regulates | pathway | 1.00 |
| AKT | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| EGFR | activates | gene | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| GENES | activates | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Cancer | activates | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Als | activates | disease | 1.00 |
| RAS | activates | gene | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ERK | encodes | gene | 0.00 |
| ALZHEIMER'S DISEASE | associated_with | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| ERK1 | activates | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| MEK | activates | protein | 0.95 |
| NUPR1 | inhibits | gene | 0.95 |
| trametinib | inhibits | drug | 0.95 |
| MEK | phosphorylates | protein | 0.95 |
| RB5 | activates | drug | 0.92 |
| SPP1 | activates | protein | 0.92 |
| FGF2/FGFR1 pathway | upstream_of | pathway | 0.90 |
| IGF1R | activates | protein | 0.90 |
| 20162012 | plays an important role in | paper | 0.90 |
| 20162012 | transmits extracellular signals from | paper | 0.90 |
| 20162012 | is activated by | paper | 0.90 |
| SRC | activates | protein | 0.90 |
| MADD | upstream_of | protein | 0.90 |
| AKT | inhibits | gene | 0.90 |
| mechanotransduction | activates | process | 0.90 |
| NLGN3 | activates | protein | 0.90 |
| AMYLOID | associated_with | protein | 0.90 |
| CHOLIX | upregulates | drug | 0.90 |
| GCN5 | modulates | protein | 0.90 |
| CREB | activates | gene | 0.90 |
| CD44 | activates | protein | 0.88 |
| TrkB | activates | protein | 0.88 |
| ITGB1 | activates | protein | 0.88 |
| GLP-1R | activates | protein | 0.85 |
| HER2 | upstream_of | protein | 0.85 |
| TQYZ | activates | drug | 0.85 |
| ketamine | activates | drug | 0.85 |
| ITE | inhibits | drug | 0.85 |
| NGF | activates | protein | 0.85 |
| SPRED1 | inhibits | protein | 0.85 |
| HSPA5 | regulates | entity | 0.85 |
| plant extracts | activates | drug | 0.85 |
| AKT | activates | gene | 0.82 |
| APOPTOSIS | inhibits | gene | 0.82 |
| VEGF | activates | protein | 0.82 |
| ASTROCYTES | associated_with | cell_type | 0.82 |
| FLAVONOIDS | regulates | gene | 0.80 |
| β2-Adrenergic Receptor | activates | receptor | 0.80 |
| phytochemicals | activates | drug | 0.80 |
| focal adhesion complexes | activates | protein | 0.80 |
| NRBP1 | participates_in | gene | 0.80 |
| hyperinsulinemia | activates | phenotype | 0.80 |
| DUSP8 | associated_with | gene | 0.80 |
| Norepinephrine | activates | compound | 0.80 |
| GPR34 | activates | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Gamma entrainment suppresses hippocampal ERK1/2 hyperactivit | 0.711 | alzheimers | Gamma entrainment therapy to restore hip |
| Astrocyte CD38-erk Mapk signaling controls mitochondrial tra | 0.380 | als-and-alzheimers | Mitochondrial transfer between neurons a |
Scientific analyses that reference this entity
neuroimmunology | 2026-04-15 | 1 hypotheses Top: 0.670
neurodegeneration | 2026-04-12 | 3 hypotheses Top: 0.887
neurodegeneration | 2026-04-04 | 18 hypotheses Top: 0.814
neurodegeneration | 2026-04-03 | 19 hypotheses Top: 0.891
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.774
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.57 · 2026-04-28
closed · Rounds: 4 · Score: 0.59 · 2026-04-27
closed · Rounds: 4 · Score: 0.12 · 2026-04-27
closed · Rounds: 4 · Score: 0.42 · 2026-04-27
closed · Rounds: 4 · Score: 0.48 · 2026-04-27
closed · Rounds: 4 · Score: 0.47 · 2026-04-27
closed · Rounds: 4 · Score: 0.52 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-27
closed · Rounds: 4 · Score: 0.73 · 2026-04-15
closed · Rounds: 4 · Score: 0.79 · 2026-04-12
Hypotheses and analyses mentioning ERK in their description or question text
No additional research found