concept

AHR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AHR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

463Connections
2Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

AHR is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ALS, Aging, Als. Connected to 274 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameAHR
Key Genes/ProteinsINFLAMMATION, SYNAPTOPHYSINSYP
Related DiseasesAls, Inflammation, Aging, Tumor, Cancer
Related PathwaysImmune Response
Linked Hypotheses2 hypotheses
🧬 3D Structure: AHR — PDB 5NJ8 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Therapeutics

index · 5665 words

Creatine for Neuroprotection

therapeutic · 3742 words

Psychobiotic Therapy for Neurodegenerative Diseases

mechanism · 3674 words

Neprilysin (NEP / CD10 / MME)

protein · 3068 words

Kidney-Brain Neurodegeneration Axis

mechanism · 2750 words

Pathway Diagram

graph TD
    AHR["AHR"]
    AHR -->|"inhibits"| SYNAPTOPHYSINSYP["SYNAPTOPHYSINSYP"]
    AHR -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
    AHR -->|"inhibits"| RAGE_NF__B["RAGE/NF-kappaB"]
    AHR -->|"inhibits"| microglia["microglia"]
    AHR -->|"regulates"| Parkinson["Parkinson"]
    AHR -->|"regulates"| Als["Als"]
    AHR -->|"activates"| Inflammation["Inflammation"]
    AHR -->|"inhibits"| Ms["Ms"]
    AHR -->|"activates"| Fibrosis["Fibrosis"]
    h_f9c6fa3f["h-f9c6fa3f"] -->|"targets"| AHR
    Indoles["Indoles"] -->|"activates"| AHR
    indoleacetic_acid["indoleacetic acid"] -->|"activates"| AHR
    BENVITIMOD["BENVITIMOD"] -->|"activates"| AHR
    CLDN1["CLDN1"] -->|"inhibits"| AHR
    NRF2["NRF2"] -->|"inhibits"| AHR
    ARNT["ARNT"] -->|"activates"| AHR
    CTSS["CTSS"] -->|"inhibits"| AHR
    P62["P62"] -->|"activates"| AHR
    CYTOKINES["CYTOKINES"] -->|"inhibits"| AHR

Outgoing (334)

TargetRelationTypeStr
Alsinhibitsdisease0.95
Inflammationactivatesdisease0.95
Inflammationinhibitsdisease0.95
INFLAMMATIONinhibitsgene0.90
Agingregulatesdisease0.85

Incoming (129)

SourceRelationTypeStr
h-f9c6fa3ftargets_genehypothesis0.90
h-f9c6fa3ftargetshypothesis0.80
INFLAMMATIONactivatesgene0.70
AGINGregulatesgene0.70
NF-ΚBregulatesgene0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ 0.612 neuroinflammation How do B cells mechanistically orchestra
Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met 0.593 neuroinflammation What molecular mechanisms determine whet

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found