Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AHR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
AHR is a concept in neurodegeneration research. Key relationships include: inhibits, activates, associated with. Associated with ALS, Aging, Als. Connected to 274 entities in the SciDEX knowledge graph.
| Name | AHR |
| Key Genes/Proteins | INFLAMMATION, SYNAPTOPHYSINSYP |
| Related Diseases | Als, Inflammation, Aging, Tumor, Cancer |
| Related Pathways | Immune Response |
| Linked Hypotheses | 2 hypotheses |
Knowledge base pages for this entity
graph TD
AHR["AHR"]
AHR -->|"inhibits"| SYNAPTOPHYSINSYP["SYNAPTOPHYSINSYP"]
AHR -.protects against.-> Alzheimer_s_disease["Alzheimer's disease"]
AHR -->|"inhibits"| RAGE_NF__B["RAGE/NF-kappaB"]
AHR -->|"inhibits"| microglia["microglia"]
AHR -->|"regulates"| Parkinson["Parkinson"]
AHR -->|"regulates"| Als["Als"]
AHR -->|"activates"| Inflammation["Inflammation"]
AHR -->|"inhibits"| Ms["Ms"]
AHR -->|"activates"| Fibrosis["Fibrosis"]
h_f9c6fa3f["h-f9c6fa3f"] -->|"targets"| AHR
Indoles["Indoles"] -->|"activates"| AHR
indoleacetic_acid["indoleacetic acid"] -->|"activates"| AHR
BENVITIMOD["BENVITIMOD"] -->|"activates"| AHR
CLDN1["CLDN1"] -->|"inhibits"| AHR
NRF2["NRF2"] -->|"inhibits"| AHR
ARNT["ARNT"] -->|"activates"| AHR
CTSS["CTSS"] -->|"inhibits"| AHR
P62["P62"] -->|"activates"| AHR
CYTOKINES["CYTOKINES"] -->|"inhibits"| AHR| Target | Relation | Type | Str |
|---|---|---|---|
| Als | inhibits | disease | 0.95 |
| Inflammation | activates | disease | 0.95 |
| Inflammation | inhibits | disease | 0.95 |
| INFLAMMATION | inhibits | gene | 0.90 |
| Aging | regulates | disease | 0.85 |
| SYNAPTOPHYSINSYP | inhibits | gene | 0.80 |
| Immune Response | regulates | pathway | 0.80 |
| Als | regulates | disease | 0.75 |
| Als | therapeutic_target | disease | 0.75 |
| Inflammation | regulates | disease | 0.75 |
| Tumor | inhibits | disease | 0.75 |
| Als | activates | disease | 0.75 |
| Cancer | regulates | disease | 0.75 |
| Nf-Κb | regulates | pathway | 0.70 |
| Microbiota | inhibits | pathway | 0.70 |
| Cancer | associated_with | disease | 0.65 |
| Cardiovascular | associated_with | disease | 0.65 |
| Dementia | associated_with | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Senescence | regulates | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Hepatitis | associated_with | disease | 0.65 |
| Glioblastoma | associated_with | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Obesity | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Leukemia | associated_with | disease | 0.65 |
| Autoimmune | associated_with | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| Glaucoma | inhibits | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Ischemia | regulates | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-f9c6fa3f | targets_gene | hypothesis | 0.90 |
| h-f9c6fa3f | targets | hypothesis | 0.80 |
| INFLAMMATION | activates | gene | 0.70 |
| AGING | regulates | gene | 0.70 |
| NF-ΚB | regulates | gene | 0.70 |
| CANCER | regulates | gene | 0.70 |
| BENVITIMOD | activates | drug | 0.64 |
| CLDN1 | inhibits | gene | 0.60 |
| NRF2 | inhibits | gene | 0.60 |
| ARNT | activates | gene | 0.60 |
| CTSS | inhibits | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| LAMP2 | inhibits | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| MYC | regulates | gene | 0.60 |
| XPA | regulates | gene | 0.60 |
| CLOCK | interacts_with | gene | 0.60 |
| PDIA3 | regulates | gene | 0.60 |
| BMAL1 | interacts_with | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| BCL2L1 | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| CYCS | therapeutic_target | gene | 0.60 |
| EGF | associated_with | gene | 0.60 |
| HSP90AA1 | therapeutic_target | gene | 0.60 |
| CASP3 | therapeutic_target | gene | 0.60 |
| RORA | associated_with | gene | 0.60 |
| BMP7 | associated_with | gene | 0.60 |
| CX3CR1 | associated_with | gene | 0.60 |
| STAT6 | activates | gene | 0.60 |
| OCLN | inhibits | gene | 0.60 |
| APP | activates | gene | 0.60 |
| FOS | regulates | gene | 0.60 |
| TLR4 | regulates | gene | 0.60 |
| AKT | regulates | gene | 0.60 |
| PI3K | regulates | gene | 0.60 |
| TLR4 | inhibits | gene | 0.60 |
| PI3K | inhibits | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| HK2 | inhibits | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| NEPRILYSIN | activates | gene | 0.60 |
| IDO1 | activates | gene | 0.60 |
| AADC | regulates | gene | 0.60 |
| TAAR1 | regulates | gene | 0.60 |
| ANGPT1 | activates | gene | 0.60 |
| NOTCH3 | activates | gene | 0.60 |
| VEGF | activates | gene | 0.60 |
| RORC | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ | 0.612 | neuroinflammation | How do B cells mechanistically orchestra |
| Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met | 0.593 | neuroinflammation | What molecular mechanisms determine whet |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 20 hypotheses Top: 0.617
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||