gene

KCA1A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KCA1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

KCA1A encodes the alpha subunit of the large-conductance calcium-activated potassium (BK) channel, critical for neuronal excitability, synaptic plasticity, and implicated in Alzheimer's and Parkinson's diseases

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🧬 Gene Info

Gene Symbol	KCA1A
Full Name	Potassium Calcium-Activated Channel Subfamily M Member 1
Chromosome	10p12
Function	KCNMB1-4 (β1-4): Beta subunits that modify channel kinetics and pharmacology
Molecular Weight	125 kDa
Amino Acids	1000 aa
Exons	26
UniProt ID	[Q12791](https://www.uniprot.org/uniprot/Q12791)
Ensembl ID	ENSG00000156170
GeneCards	KCA1A
Human Protein Atlas	KCA1A
KCNMB1-4 (β1-4)	Beta subunits that modify channel kinetics and pharmacology
KCNIP1-4 (γ1-4)	Gamma subunits that sense intracellular signaling molecules
Conductance	~200-250 pS in physiological K+ gradients (among the largest K+ conductances)
Selectivity	Highly selective for K+ over Na+ and Ca2+
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCA1A Gene

gene · 1103 words

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Pathway Diagram

graph TD
    KCA1A["KCA1A"]
    neurodegeneration["neurodegeneration"]
    KCA1A -->|"implicated_in"| neurodegeneration
    style KCA1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning KCA1A in their description or question text

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