gene

KDM3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

6Outgoing

0Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	KDM3A
Chromosome	2p11.2
Protein Type	Enzyme
Function	is a nuclear enzyme that catalyzes the removal of methyl groups from histone H3 at lysine 9 (H3K9), a modification associated with transcriptional repression.
Primary Expression	neurons and glial cells throughout the brain, where it regulates genes critical for neuronal survival, differentiation, synaptic plasticity, and respo
Molecular Weight	164 kDa
Amino Acids	474 aa
Exons	23
UniProt ID	Q9N3T2
NCBI Gene ID	55630
Ensembl ID	ENSG00000188290
OMIM	607442
GeneCards	KDM3A
Human Protein Atlas	KDM3A
Associated Diseases	neurodegeneration
Interactions	CANCER, HIF1, HIF1A, UBIQUITIN
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KDM3A — AlphaFold Q9N3T2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KDM3A Gene (JMJD1A)

gene · 3347 words

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KDM3A Protein

protein · 829 words

→

Pathway Diagram

graph TD
    KDM3A["KDM3A"]
    Cancer{"Cancer"}
    KDM3A -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    KDM3A -->|"activates"| Carcinoma
    UBIQUITIN["UBIQUITIN"]
    KDM3A -->|"activates"| UBIQUITIN
    HIF1["HIF1"]
    KDM3A -->|"activates"| HIF1
    HIF1A["HIF1A"]
    KDM3A -->|"activates"| HIF1A
    CANCER["CANCER"]
    KDM3A -->|"activates"| CANCER
    neurodegeneration["neurodegeneration"]
    KDM3A -->|"implicated in"| neurodegeneration
    style KDM3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
UBIQUITIN	activates	gene	0.60
HIF1A	activates	gene	0.60
HIF1	activates	gene	0.60
CANCER	activates	gene	0.60

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KDM3A in their description or question text

No additional research found