concept

HIF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

546Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HIF1 is a concept in neurodegeneration research. Key relationships include: interacts with, regulates, activates. Associated with AD, ALI, ALS. Connected to 279 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	HIF1
Key Genes/Proteins	BNIP3, MTOR, NIX, CANCER
Related Diseases	Cancer, Dementia, Alzheimer, Als, Cardiovascular
Related Pathways	Mtor, oxidative stress response, autophagy pathway

Wiki Pages (10)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HIF1["HIF1"]
    HIF1 -->|"activates"| BNIP3["BNIP3"]
    HIF1 -->|"interacts"| Dementia["Dementia"]
    HIF1 -->|"interacts"| Alzheimer["Alzheimer"]
    HIF1 -->|"interacts"| Als["Als"]
    HIF1 -->|"interacts"| Cardiovascular["Cardiovascular"]
    HIF1 -->|"interacts"| Parkinson["Parkinson"]
    HIF1 -->|"interacts"| Ms["Ms"]
    HIF1 -->|"activates"| Carcinoma["Carcinoma"]
    HIF1 -->|"activates"| Cancer["Cancer"]
    HIF1 -->|"activates"| Cardiac["Cardiac"]
    CMVS["CMVS"] -->|"activates"| HIF1
    MFN1["MFN1"] -->|"interacts"| HIF1
    DNM1L["DNM1L"] -->|"interacts"| HIF1
    DDIT3["DDIT3"] -->|"interacts"| HIF1
    ABCD3["ABCD3"] -->|"interacts"| HIF1
    LMNA["LMNA"] -->|"interacts"| HIF1
    MAP1LC3B["MAP1LC3B"] -->|"interacts"| HIF1
    OPTN["OPTN"] -->|"interacts"| HIF1
    AMBRA1["AMBRA1"] -->|"interacts"| HIF1
    CTSD["CTSD"] -->|"interacts"| HIF1

Outgoing (313)

Target	Relation	Type	Str
BNIP3	activates	protein	0.80
Cancer	regulates	disease	0.75
NIX	regulates	protein	0.74
MTOR	activates	gene	0.70
Mtor	activates	pathway	0.70
CANCER	regulates	gene	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Dementia	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Cardiovascular	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Cardiac	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Frontotemporal Dementia	interacts_with	disease	0.65
Ftd	interacts_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	activates	disease	0.65
Ischemia	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Inflammation	activates	disease	0.65
Cardiac	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Hypertension	expressed_in	disease	0.65
Tumor	causes	disease	0.65
Carcinoma	causes	disease	0.65
Cancer	causes	disease	0.65
Cardiovascular	causes	disease	0.65
ALS	regulates	disease	0.65
Ulcerative Colitis	activates	disease	0.65

Incoming (233)

Source	Relation	Type	Str
Ros	activates	compound	0.80
MTOR	promotes	protein	0.80
CMVS	activates	protein	0.64
MFN1	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
DDIT3	interacts_with	gene	0.60
ABCD3	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
MAP1LC3B	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
AMBRA1	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60
MUL1	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
BNIP3L	interacts_with	gene	0.60
HIF1A	interacts_with	gene	0.60
GBA	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
AMPK	interacts_with	gene	0.60
NDP52	interacts_with	gene	0.60
RHOT1	interacts_with	gene	0.60
BNIP3	regulates	gene	0.60
FOXO3	regulates	gene	0.60
NRF2	regulates	gene	0.60
MITOPHAGY	regulates	gene	0.60
P62	regulates	gene	0.60
ERK	activates	gene	0.60
DUSP9	activates	gene	0.60
FOXO3	activates	gene	0.60
BNIP3	activates	gene	0.60
P53	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
KDM3A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
CD44	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
BCL2L11	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
NIX	interacts_with	gene	0.60
MTOR	causes	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
ROS	regulates	gene	0.60
LC3	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
NIX	regulates	gene	0.60
P62	interacts_with	gene	0.60
DISC1	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HIF1

Understanding Entity Pages

Summary

Wiki Pages (10)

Novel Therapy Index

HIF/Hypoxia Signaling in Parkinson's Disease

Hypoxia Neuroprotection in Sporadic Parkinson's Disease

Therapy Ideas

DUSP9 Gene

HIF-1α Protein - Hypoxia Inducible Factor 1-alpha

HMOX1 — Heme Oxygenase 1

BNIP3 Gene