gene

HIF1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIF1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1094Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

HIF1A is a gene implicated in neurodegeneration research. Key relationships include: interacts with, therapeutic target, activates. Associated with AD, ALI, ALS. Connected to 477 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HIF
Full Name	Hypoxia Inducible Factor 1 Subunit Alpha
Chromosome	14q21.1
Function	PHD inactivation: Reduced prolyl hydroxylation
Pathways	Aerobic Glycolysis, Akt, Autophagy, Epigenetic, Immune Response
UniProt ID	Q16665
NCBI Gene ID	3091
Ensembl ID	ENSG00000100644
OMIM	603348
GeneCards	HIF
Human Protein Atlas	HIF
Associated Diseases	AD, ALI, ALS, ATHEROSCLEROSIS, Alzheimer
Interactions	MAP1LC3B, GBA, FUNDC1, AMBRA1, PINK1, BCL2L13
KG Connections	1094 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure: HIF1A — PDB 4H6J Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    HIF1A(["HIF1A"])
    Metabolic_Reprogramming("Metabolic Reprogramming")
    IDH2["IDH2"]
    Microglial_Metabolic_Reprogramming("Microglial Metabolic Reprogramming")
    AEROBIC_GLYCOLYSIS["AEROBIC GLYCOLYSIS"]
    GLYCOLYSIS["GLYCOLYSIS"]
    Aerobic_Glycolysis["Aerobic Glycolysis"]
    BMAL1["BMAL1"]
    Bladder_Tumorigenesis("Bladder Tumorigenesis")
    Cancer_Stemness("Cancer Stemness")
    HYPOXIA["HYPOXIA"]
    STRESS_GRANULE_FORMATION["STRESS GRANULE FORMATION"]
    AKT1(["AKT1"])
    VEGF(["VEGF"])
    BNIP3(["BNIP3"])

    HIF1A -->|"associated with"| Metabolic_Reprogramming
    IDH2 -->|"associated with"| HIF1A
    HIF1A -->|"associated with"| Microglial_Metabolic_Reprogramming
    HIF1A -->|"activates"| AEROBIC_GLYCOLYSIS
    HIF1A -->|"upregulates"| GLYCOLYSIS
    HIF1A -->|"regulates"| Aerobic_Glycolysis
    BMAL1 -->|"regulates"| HIF1A
    BMAL1 -->|"interacts with"| HIF1A
    HIF1A -->|"involved in"| Bladder_Tumorigenesis
    HIF1A -->|"associated with"| Cancer_Stemness
    HIF1A -->|"mediates"| HYPOXIA
    HIF1A -->|"regulates"| STRESS_GRANULE_FORMATION
    AKT1 -->|"regulates"| HIF1A
    HIF1A -->|"regulates"| VEGF
    HIF1A -->|"activates"| BNIP3

    style HIF1A fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (621)

Target	Relation	Type	Str
Metabolic Reprogramming	associated_with	process	0.95
Oxidative Stress	upregulates	process	0.95
cancer stemness	promotes	phenotype	0.93
lenvatinib resistance	drives	phenotype	0.91
Aerobic Glycolysis	regulates	pathway	0.90
Metabolic Reprogramming	mediates	process	0.90
Proinflammatory Macrophage Activation	promotes	process	0.90
ERRΑ	inhibits	protein	0.90
SLC2A1	upregulates	gene	0.90
Aerobic Glycolysis	upregulates	pathway	0.90
aerobic glycolysis	drives	process	0.90
aerobic glycolysis	associated_with	pathway	0.90
angiogenesis	promotes	process	0.90
VEGF	upregulates	gene	0.90
VEGFA	upregulates	gene	0.90
Microglial Metabolic Reprogramming	associated_with	process	0.90
AEROBIC GLYCOLYSIS	activates	entity	0.90
GLYCOLYSIS	upregulates	entity	0.90
NEURODEGENERATION	involved_in	disease	0.90
HK2	upregulates	gene	0.88
PFKFB3	upregulates	gene	0.88
Bladder Tumorigenesis	involved_in	process	0.85
Cancer Stemness	associated_with	phenotype	0.85
Photoreceptor Cells	causes	cell_type	0.85
HYPOXIA	mediates	entity	0.85
STRESS GRANULE FORMATION	regulates	entity	0.85
Glycolysis	upregulates	pathway	0.85
Oxidative Stress	regulates	process	0.85
PARKINSON'S DISEASE	involved_in	disease	0.85
ALZHEIMER'S DISEASE	involved_in	disease	0.85
ATHEROSCLEROSIS	associated_with	disease	0.85
Angiogenesis	promotes	process	0.85
VEGF	regulates	gene	0.80
BNIP3	activates	protein	0.80
BDNF	regulates	protein	0.80
MTOR	interacts_with	gene	0.80
DJ1	interacts_with	gene	0.80
Bladder Cancer	associated_with	disease	0.80
Macrophage	expressed_in	cell_type	0.80
MITOCHONDRIA	regulates	cell_type	0.80
Neuroprotection	promotes	process	0.80
ferroptosis	regulates	process	0.78
Cancer	therapeutic_target	disease	0.75
Fibrosis	therapeutic_target	disease	0.75
Als	therapeutic_target	disease	0.75
Cardiovascular	therapeutic_target	disease	0.75
Aging	therapeutic_target	disease	0.75
Inflammation	associated_with	disease	0.75
ischemic stroke	associated_with	disease	0.70
UBIQUITIN	activates	gene	0.70

Incoming (473)

Source	Relation	Type	Str
IDH2	associated_with	entity	0.95
USP22	deubiquitinates	protein	0.95
Autophagy	degrades	process	0.95
VHL	degrades	gene	0.93
BMAL1	regulates	gene	0.90
BMAL1	interacts_with	entity	0.90
UBIQUITIN	modulates	protein	0.90
JAK1/STAT1/3	activates	pathway	0.90
ERRΑ	stabilizes	protein	0.90
Wnt Signaling	activates	pathway	0.90
SIRT3	inhibits	gene	0.90
h-646ae8f1	targets_gene	hypothesis	0.90
AKT1	regulates	protein	0.85
HVCN1	upregulates	gene	0.85
Pi3K/Akt Pathway	regulates	pathway	0.85
APOE4 Microglia	upregulates	cell_type	0.85
PI3K/Akt	activates	pathway	0.85
cardamom nanoemulsion	downregulates	compound	0.85
PI3K/AKT	regulates	pathway	0.85
HV1	upregulates	gene	0.85
PIK3CA	activates	gene	0.82
AKT1	activates	gene	0.82
NLRP3 inhibition	contributes_to	phenotype	0.80
PDI	activates	protein	0.80
EGLN2	inhibits	gene	0.80
FOXO3	interacts_with	protein	0.75
TNF	associated_with	gene	0.70
BAX	activates	gene	0.70
BAX	inhibits	gene	0.70
BCL2	inhibits	gene	0.70
APOPTOSIS	activates	gene	0.70
ATP	activates	gene	0.65
FRONTOTEMPORAL DEMENTIA	causes	disease	0.65
AMYLOID	interacts_with	protein	0.65
sorafenib	regulates	drug	0.64
STAT1	activates	protein	0.64
STAT3	activates	protein	0.64
CAT	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
DNM1L	interacts_with	gene	0.60
CANX	interacts_with	gene	0.60
LGALS3	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
G3BP1	interacts_with	gene	0.60
PEX3	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
BCL2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
STING1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HIF1A

Understanding Entity Pages

Summary

Wiki Pages (21)

HIF1A Gene - Hypoxia Inducible Factor 1 Subunit Alpha

deferiprone-neurodegeneration

TIGAR - TP53-Induced Glycolysis and Apoptosis Regulator

DJ1 — Park7 (Parkinsonism-Associated Deglycase)

SLC2A1 Gene

Hypoxia Response Pathway

HIF1AN — Hypoxia Inducible Factor 1 Subunit Alpha Inhibitor

HIF/Hypoxia Signaling in Parkinson's Disease

TNFAIP6 — TNF Alpha Induced Protein 6 (TSG-6)

HIF/Hypoxia Signaling in Parkinson's Disease

HIF-1α (Hypoxia-Inducible Factor 1-Alpha)

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

DHODH — Dihydroorotate Dehydrogenase

IREB2 — Iron Responsive Element Binding Protein 2

MS4A2 Gene (FcεRIβ)

RPS6KA1 — Ribosomal Protein S6 Kinase A1

PIEZO1 — Piezo Type Mechanosensitive Ion Channel Component 1

CAPN1 Gene

VEGFR1 (FLT1) Protein

CTSL Gene