gene

KLF14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KLF14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

8Outgoing

1Incoming

Summary

Gene page for KLF14 (Kruppel-Like Factor 14), a transcription factor associated with type 2 diabetes, metabolic syndrome, and increasingly recognized in neurodegeneration.

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🧬 Gene Info

Gene Symbol	KLF14 (BTEB1)
Full Name	Krüppel-Like Factor 14
Aliases	BTEB1, DKFZp434J0225
Chromosome	7q32.3
Protein Type	Transcription Factor
Function	is a zinc-finger transcription factor belonging to the KLF family of transcriptional regulators.
Amino Acids	479 aa
Pathways	PPARα
UniProt ID	Q9C0A6
NCBI Gene ID	51684
Ensembl ID	ENSG00000178295
Protein Length	479 amino acids
Mechanism	Target Genes
Direct activation	PPARγ, adiponectin
Direct repression	Inflammatory cytokines
Associated Diseases	neurodegeneration
Interactions	SOCS3, WNT3A, HK2
KG Connections	9 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KLF14 — AlphaFold Q9C0A6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KLF14 Gene

gene · 1031 words

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Pathway Diagram

graph TD
    KLF14["<b>KLF14</b>"]
    TRIM59["TRIM59"]
    KLF14 -->|"associated with"| TRIM59
    SOCS3["SOCS3"]
    KLF14 -->|"activates"| SOCS3
    PPAR_(["PPARalpha"])
    KLF14 -->|"activates"| PPAR_
    WNT3A["WNT3A"]
    KLF14 -->|"inhibits"| WNT3A
    HK2["HK2"]
    KLF14 -->|"inhibits"| HK2
    GPX4["GPX4"]
    KLF14 -->|"downregulates"| GPX4
    LDHB["LDHB"]
    KLF14 -->|"downregulates"| LDHB
    NF__B(["NF-kappaB"])
    KLF14 -->|"inhibits"| NF__B
    neurodegeneration["neurodegeneration"]
    KLF14 -->|"implicated in"| neurodegeneration
    miR_346["miR-346"]
    miR_346 -->|"regulates"| KLF14
    style KLF14 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
TRIM59	associated_with	gene	0.80
SOCS3	activates	gene	0.80
PPARα	activates	pathway	0.80
WNT3A	inhibits	gene	0.80
HK2	inhibits	gene	0.80
GPX4	downregulates	gene	0.80
LDHB	downregulates	gene	0.80
NF-κB	inhibits	pathway	0.80

Incoming (1)

Source	Relation	Type	Str
miR-346	regulates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found