concept

LDHB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDHB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

96Connections

0Hypotheses

1Analyses

50Outgoing

38Incoming

0Experiments

1Debates

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💡 Concept Info

Name	LDHB
Key Genes/Proteins	Akt, AKT, AMPK, AND, ATP, BRAIN INJURY
Related Diseases	Als, Cancer, Covid
Related Pathways	apoptosis pathway, Calcium Signaling

Pathway Diagram

graph TD
    LDHB["LDHB"]
    LDHB -->|"involved_in"| Glycolysis["Glycolysis"]
    LDHB -->|"activates"| Tumor["Tumor"]
    LDHB -->|"activates"| Cancer["Cancer"]
    LDHB -->|"activates"| Infection["Infection"]
    LDHB -->|"activates"| Covid["Covid"]
    LDHB -->|"activates"| Als["Als"]
    LDHB -->|"activates"| PTEN["PTEN"]
    LDHB -->|"activates"| CANCER["CANCER"]
    LDHB -->|"activates"| HIF_1_["HIF-1Alpha"]
    KLF14["KLF14"] -->|"downregulates"| LDHB
    HIF["HIF"] -->|"activates"| LDHB
    PI3K["PI3K"] -->|"activates"| LDHB
    HK2["HK2"] -->|"activates"| LDHB
    MTOR["MTOR"] -->|"activates"| LDHB
    SRC["SRC"] -->|"activates"| LDHB
    GENES["GENES"] -->|"activates"| LDHB
    HK1["HK1"] -->|"activates"| LDHB
    AMPK["AMPK"] -->|"activates"| LDHB
    G6PD["G6PD"] -->|"activates"| LDHB

Outgoing (58)

Target	Relation	Type	Str
h-b701c493b0	targeted_by	hypothesis	1.00
Glycolysis	associated_with	process	0.90
Cancer	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Tumor	activates	disease	0.65
Covid	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
Infection	activates	disease	0.65
VCAM1	biomarker_for	gene	0.60
MAP2K1	biomarker_for	gene	0.60
LMNA	biomarker_for	gene	0.60
Unfolded Protein Response	biomarker_for	pathway	0.60
Calcium Signaling	biomarker_for	pathway	0.60
Glycolysis	biomarker_for	pathway	0.60
Sphingolipid	biomarker_for	pathway	0.60
GENES	activates	gene	0.60
SRC	activates	gene	0.60
G6PD	activates	gene	0.60
MTOR	activates	gene	0.60
GLUT3	activates	gene	0.60
PI3K	activates	gene	0.60
HK2	activates	gene	0.60
HK1	activates	gene	0.60
FASN	activates	gene	0.60
GLUT1	activates	gene	0.60
MAPT	expressed_in	gene	0.60
SNCB	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
Glycolysis	activates	pathway	0.60
CANCER	activates	gene	0.60
HIF-1Α	activates	gene	0.60
LDHA	activates	gene	0.60
Oxidative Phosphorylation	activates	pathway	0.60
PTEN	activates	gene	0.60
Mtor	activates	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Mitophagy	activates	pathway	0.60
ENO1	biomarker_for	gene	0.60
Akt	activates	protein	0.60
Hif-1	activates	protein	0.60
Ras	activates	protein	0.60
NDUFS6	expressed_in	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
AND	activates	gene	0.60
AMPK	activates	gene	0.60

Incoming (38)

Source	Relation	Type	Str
h-b701c493b0	targets	hypothesis	1.00
PAL	upregulates	compound	0.80
KLF14	downregulates	gene	0.80
HIF	activates	gene	0.60
PI3K	activates	gene	0.60
HK2	activates	gene	0.60
MTOR	activates	gene	0.60
SRC	activates	gene	0.60
GENES	activates	gene	0.60
HK1	activates	gene	0.60
AMPK	activates	gene	0.60
G6PD	activates	gene	0.60
AKT	activates	gene	0.60
FASN	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
SIRT1	activates	gene	0.60
GAPDH	biomarker_for	gene	0.60
PKM	activates	gene	0.60
LDHA	activates	gene	0.60
GLUT1	activates	gene	0.60
GENES	expressed_in	gene	0.60
SNCB	expressed_in	gene	0.60
HSPE1	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
BRAIN INJURY	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
ATP	protects_against	gene	0.60
MITOPHAGY	activates	gene	0.60
NDUFS6	expressed_in	gene	0.60
AND	activates	gene	0.60
CANCER	associated_with	gene	0.60
GLUT3	activates	gene	0.60
ATP	phosphorylates	gene	0.55
HIF-1Α	activates	protein	0.50
GLYCOLYSIS	activates	pathway	0.50
Cortex	expressed_in	brain_region	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

test

neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.609

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

test

closed · Rounds: 4 · Score: 0.65 · 2026-04-16

Related Research

Hypotheses and analyses mentioning LDHB in their description or question text

No additional research found